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Chemical Name: Acetonitrile-D3
Synonyms: Deuterated Acetonitrile
Chemical Formula: CD3CN
Molecular Weight: 44.08 g/mol
Physical Form: Clear, colorless liquid
Smell: Ether-like odor noticed in most labs
Key Hazards: Flammable liquid and vapor, can irritate eyes and skin, can harm organs if inhaled or swallowed, dangerous if absorbed through skin
Risk Phrases: Highly flammable, toxic by inhalation, in contact with skin, or if swallowed
Precautionary Statements: Avoid open flames, keep containers closed, use only where ventilation works well, limit skin exposure, ensure no water sources get contaminated in case of leaks or spills
Possible Symptoms: Headache, dizziness, nausea, sore throat, irritation to skin and eyes from splashes or vapors
Main Component: Acetonitrile-D3 (CD3CN, purity usually above 99.5%)
Impurities: Trace amounts of non-deuterated acetonitrile, water, or other deuterated byproducts can be present, but at low levels compared to the primary substance
Inhalation: Move person to fresh air right away, loosen tight clothing, keep airway clear, seek medical attention if breathing feels labored or shallow
Skin Contact: Rinse skin immediately with plenty of water using emergency showers when available, remove contaminated clothing, watch for signs of irritation
Eye Contact: Flush eyes for at least 15 minutes with water, making sure eyelids are held apart, go for medical help fast
Ingestion: Do not induce vomiting, rinse mouth with water if person awake, get emergency help without delay
Suitable Extinguishing Media: Carbon dioxide, dry powder, foam, never water streams directly on liquid
Personal Protective Gear: Wear full protective gear and self-contained breathing devices
Special Hazards: Vapors form flammable mixtures with air, can travel distances to ignite, heat releases toxic gases (hydrogen cyanide, nitrogen oxides, carbon monoxide)
Firefighting Tips: Keep containers cool with water, fight fire from safe distance, avoid breathing smoke or fumes
Personal Protection: Ventilate before entering spill area, wear gloves and goggles, stop source of leak if safe
Spill Response: Absorb spill with inert material (sand, vermiculite), collect in closed, labeled containers, do not allow to reach drains or water courses
Clean-Up: Dispose of cleanup materials as hazardous waste, wash smaller residues away with plenty of water, always ensure proper PPE for workers
Handling Advice: Use only in well-ventilated fume hoods, avoid direct contact with liquid or vapor, keep all ignition sources away from work zones
Storage Recommendations: Store in tightly closed bottles, away from heat or sunlight, separate from acids, oxidizers, and bases, stash in fireproof cabinets where possible
Special Rules: Never return unused material to stock bottle, label all containers, avoid rough handling to reduce spills or breakages
Engineering Controls: Use fume hoods or local exhaust, add chemical splash shields for extra safety
Personal Protective Equipment: Nitrile or neoprene gloves, chemical-resistant goggles or face shields, lab coats or aprons, use respirators only if ventilation fails
Exposure Limits: Regulatory agencies set threshold limit values for acetonitrile; levels generally range between 20-40 ppm for time-weighted averages, check local regulations for deuterated variants
Hygiene Practices: Wash up before eating or drinking, keep food out of chemical use areas, strip off all protective gear before leaving lab
Appearance: Clear liquid
Boiling Point: About 81.6°C
Melting Point: -45°C
Density: Roughly 0.79 g/cm³ at 20°C
Solubility: Miscible with water, alcohol, ether
Vapor Pressure: Near 88 mmHg at 20°C
Flash Point: Close to 6°C (open cup)
Odor: Faint, ether-like scent stands out even with small leaks
Stability: Remains stable under usual storage, breaks down when heated or exposed to strong acids
Hazardous Reactions: Can react with strong oxidants, acids, or alkali metals, which lead to heat and toxic gases
Decomposition Products: Hydrogen cyanide, carbon monoxide, nitrogen oxides released during high heat, fires, or contact with incompatible materials
Incompatibilities: Avoid mixing with strong acids, bases, oxidizers, and reducing agents
Inhalation Effects: Breathing in vapor can cause dizziness or headache, higher levels can be fatal due to effects on the central nervous system and internal organs
Skin Contact: Causes pain, redness, and blistering with prolonged or repeated skin contact
Eye Contact: Stings and burns eyes quickly, can damage the cornea with enough exposure
Ingestion: Swallowing even small amounts can cause nausea, confusion, rapid heartbeat, and in severe cases dangerous drops in blood pressure and respiratory distress
Long-Term Exposure: May target liver and kidneys, workers need regular health monitoring to pick up problems early
Environmental Impact: Acetonitrile-D3 breaks down over time in soil and water, but spills can kill aquatic life and harm plants at high levels
Persistence and Degradation: Biodegradation happens, but not fast enough for big spills, always take action to prevent reaching drains and fresh water
Bioaccumulation: Evidence so far does not point to serious buildup in living things, but environmental agencies treat it as a potential hazard due to acute toxicity for fish and invertebrates
Recommended Disposal: Send waste and contaminated items to licensed chemical waste handlers, never pour down the drain or general trash, collect even small amounts as hazardous waste
Recycle and Recovery: Some labs send spent solvent for solvent recovery if contamination is low, check local facilities
Precautions: Label waste containers, store sealed until pick-up, never mix with incompatible materials to avoid fire or toxic gas risks for disposal workers
Transport Restrictions: Classified as flammable liquid, strict controls exist for shipping by road, air, or sea
Labeling: Containers must show clear hazard tags for fire and toxic risk, shippers face stiff fines for mislabeling
Packing: Use UN-approved flammable liquid containers, secondary containment to stop leaks or breakages, transport by trained handlers only
Spill Response in Transit: Emergency procedures focus on rapid containment and ventilation, local fire brigades may need alert if large amounts escape
Global Regulations: Major chemical regulations (REACH, TSCA) cover acetonitrile-D3 due to flammability and toxicity, strict controls for handling, labeling and worker exposure
Personal Precautions: Lab workers and shippers usually need safety training, health monitoring, and compliance checks
Workplace Requirements: Employers must run regular hazard assessments, fit out labs with spill kits, fire extinguishers, and emergency eyewash or showers, periodic safety audits are routine to catch gaps
