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Product Name: Acetamide
Chemical Formula: C2H5NO
CAS Number: 60-35-5
Synonyms: Ethanamide
Recommended Uses: Laboratory chemical, chemical intermediate, solvent, organic synthesis
Manufacturer Information: Typically found on the container label, essential for tracing the batch and gaining more details in case of emergencies
Emergency Contact: Local poison control center or designated workplace number
GHS Classification: Acute toxicity (Oral, Category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Carcinogenicity (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, suspected of causing cancer
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust and vapors, wear protective gloves and eye protection, wash thoroughly after handling, do not eat or drink while using, get medical attention if exposed or feeling unwell
Exposure Routes: Inhalation, ingestion, skin and eye contact
Substance: Pure acetamide
Chemical Name: Acetamide
Concentration: 100%
CAS Number: 60-35-5
Impurities or Stabilizing Additives: Usually absent in reagent-grade material
Inhalation: Move person to fresh air, support breathing with oxygen if necessary, seek medical advice for persistent symptoms
Skin Contact: Remove contaminated clothing, rinse skin using plenty of water, clean gently with soap, seek medical attention for persistent irritation
Eye Contact: Rinse eyes with water for at least 15 minutes, hold eyelids open, seek ophthalmological care if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting without medical advice, seek immediate medical attention
Most Important Symptoms: Eye and skin redness, stomach pain, nausea, headache, possible long-term carcinogenic risk
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Hazards Arising From Combustion: Releases toxic fumes including nitrogen oxides, carbon monoxide, carbon dioxide, ammonia
Protective Equipment Required: Firefighters should use self-contained breathing apparatus and full protective gear
Special Procedures: Cool exposed containers with water spray, prevent run-off from entering sewers or waterways
Personal Precautions: Use personal protective equipment, ventilate area, avoid inhaling dust, prevent contact with eyes or skin
Environmental Precautions: Avoid release to the environment, do not flush into drains, prevent entry to waterways
Clean-Up Procedures: Sweep or scoop spilled material using non-sparking tools, collect in tightly sealed containers for proper disposal, wash affected area with water after removal of residues
Notification: Report large spills according to local, regional, or national regulations
Handling: Use proper ventilation, avoid generating dust, handle with clean gloves and safety eyewear, use only with local exhaust or properly filtered fume hoods, minimize spills and splashes, do not ingest or inhale
Storage: Keep in tightly closed containers, store in cool, dry, well-ventilated locations away from incompatible substances such as strong acids or bases, keep away from sources of ignition, segregation from food and beverages essential to avoid accidental ingestion
Occupational Exposure Limits: OSHA and ACGIH do not specify exact PEL or TLV, but keeping airborne concentrations as low as reasonably achievable reduces risk
Engineering Controls: Use fume hood and local ventilation, equipment with dust extraction preferred
Personal Protection Equipment (PPE): Chemically resistant gloves, safety goggles, lab coat, respiratory protection if dust may form, emergency eyewash and showers on site
Hygiene Practices: Wash hands before eating or drinking, remove contaminated clothing before leaving work area
Molecular Formula: C2H5NO
Molecular Weight: 59.07 g/mol
Appearance: White crystalline solid
Odor: Slightly like ammonia
Melting Point: 78°C
Boiling Point: 221°C
Solubility: Miscible with water
Vapor Pressure: 0.08 mmHg (25°C)
Density: 1.159 g/cm³ (20°C)
pH Value (1% solution): About 9
Flash Point: 176°C
Partition Coefficient (n-octanol/water): -1.26
Evaporation Rate: Not fast under ambient conditions
Chemical Stability: Stable under recommended storage conditions
Possible Reactions: Can react with strong oxidizers, acids, and bases
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, ammonia released upon heating
Conditions to Avoid: Excessive heat, moisture, incompatible chemicals, sources of ignition
Polymerization: Does not occur under normal procedures in the lab
Acute Oral Toxicity (LD50): 1000 mg/kg (rat)
Inhalation: Irritation of respiratory tract, coughing, or difficulty breathing possible with dust
Skin and Eye Irritation: Both skin and eye contact produce redness and discomfort, prolonged exposure increases severity
Carcinogenicity: Possible human carcinogen, included in IARC Group 2B
Chronic Effects: Repeated high-level exposure increases risk for kidneys and liver
Routes of Exposure: Inhalation, ingestion, skin absorption possible
Other Data: Not mutagenic or teratogenic based on current available information
Ecotoxicity: Low toxicity to aquatic organisms, but presence in water bodies not recommended
Mobility in Soil: High, given miscibility, can leach through soil to groundwater
Persistence and Degradability: Biodegradable in natural environments, degradation occurs relatively quickly
Bioaccumulative Potential: Low likelihood due to solubility and metabolism in organisms
Other Adverse Effects: Excessive release to environment contributes to chemical load; responsible disposal remains best practice
Waste Disposal Methods: Dispose as hazardous waste according to local, regional, and national laws, avoid direct discharge to sewer system or natural waters
Contaminated Packaging: Rinse empty containers thoroughly and dispose or recycle according to chemical waste handling protocols
Recommended Treatment: High-temperature incineration at authorized waste facilities ensures breakdown of toxic components
UN Number: Not regulated for ground or air transport using standard packing for laboratory chemicals
Proper Shipping Name: Not subject to specific transport regulations as dangerous goods
Packing Group: Not assigned
Environmental Hazards: Not considered hazardous for marine or aquatic transport, but best to avoid uncontrolled transport or open exposure
Special Precautions: Secure tightly sealed containers, avoid heat and rough handling during transit
TSCA Inventory: Listed
EU Classification: Harmful; Carcinogen Category 2
OSHA Hazard Communication: Included as hazardous chemical, workplace labeling required
SARA Title III: Not listed as an extremely hazardous material
State Regulations: Various US states include acetamide as a carcinogen on safety notifications; compliance with Proposition 65 in California applies
Other Regulatory Listings: Subject to workplace safety programs, chemical hygiene plans, and record-keeping for hazardous chemicals in most settings where used
