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Name: 5-Ethynyluridine
Chemical Formula: C9H8N2O6
Description: This compound often appears as a white or off-white powder and finds popularity in biochemical research for RNA labeling.
Synonyms: No widely used synonym, but some refer to it by its chemical structure or abbreviation (EU).
Hazard Classification: Irritant effect on eyes, skin, or respiratory system gets flagged on many safety references.
Possible Routes of Exposure: Skin contact, eye contact, ingestion, and inhalation.
Physical Hazards: Dust formation may happen during handling, causing irritation.
Health Hazards: Similar nucleoside analogs have shown cytotoxic effects in lab settings. Evidence around 5-Ethynyluridine itself remains limited, but great caution helps limit exposure.
Precautionary Statements: Avoid inhaling dust, prevent skin and eye contact, and keep the workspace well-ventilated.
Chemical Identity: 5-Ethynyluridine
Purity: Products supplied for research commonly list high purity, often above 98%.
Impurities: Trace amounts may be present but generally not specified outside technical data from suppliers.
Molecular Weight: 224.17 g/mol
Inhalation: Move to fresh air and seek medical attention if symptoms show up.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, and continue rinsing.
Skin Contact: Wash skin with soap and water, remove contaminated clothing.
Ingestion: Rinse mouth with plenty of water and get medical help if feeling unwell.
Most Important Symptoms/Effects: Irritation of eyes, skin, mucous membranes; no broad evidence of toxicity in humans, but nucleoside analogs often act as cell toxins at higher exposures.
Suitable Extinguishing Media: Use dry chemical, CO2, or water spray. Avoid strong blasts of water.
Specific Hazards: During fires, hazardous gases such as nitrogen oxides and carbon oxides may form.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective gear.
Personal Precautions: Use personal protective equipment. Avoid dust generation.
Spill Cleanup: Sweep up, shovel, or vacuum the material and place in appropriate disposal container.
Environmental Precautions: Prevent the product from entering drains and waterways.
Ventilation: Boost airflow in the affected area to disperse dust and vapors.
Handling: Wear personal protective equipment including gloves, lab coats, and safety glasses. Avoid breathing dust or making skin contact.
Hygiene Measures: Wash hands thoroughly after handling.
Storage: Keep container tightly closed in a cool, dry, and well-ventilated location. Store away from incompatible materials such as strong acids or oxidizers.
Engineering Controls: Work in chemical fume hood when practical. Use local exhaust ventilation.
Personal Protection: Safety goggles, chemical-resistant gloves, and lab coats provide a barrier against exposure.
Respiratory Protection: Use appropriate masks if dust becomes unavoidable.
Appearance: White or off-white powder
Odor: Odorless or very faint odor
Solubility: Water-soluble at typical research concentrations
Melting Point: Specific value rarely published; most suppliers note a range aligned with nucleoside analogs (approximately 220-240°C)
Boiling Point: Decomposition before boiling
pH: Not defined in solid form; solutions tend to be neutral in physiological buffers
Chemical Stability: This material stands up to recommended storage at room temperature, in dry and dark conditions.
Reactivity: Reacts with strong acids, strong bases, and oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, and carbon dioxide may result from fire or excessive heat.
Acute Toxicity: Research indicates minimal risk under standard conditions, but ingestion, inhalation, or injection may harm cells over time due to its function as a uridine analog.
Skin and Eye Irritation: May cause irritation due to dust or residual powders on surfaces.
Chronic Effects: Evidence about chronic exposure is sparse. Given its structural similarity to other nucleoside analogs, the body might misincorporate this into nascent RNA, disrupting cellular function at high concentrations.
Carcinogenicity: No widely recognized classification as a carcinogen.
Mutagenicity: As a nucleoside analog, potential for DNA/RNA disruption exists, though currently results remain inconclusive.
Environmental Impact: Nucleoside analogs do not break down easily, and their entry into water systems may impact microbial communities.
Persistence and Degradability: Expected to persist in aquatic systems until broken down by sunlight or chemical processes.
Bioaccumulation: Designed for cellular incorporation, so can affect natural organisms exposed to it.
Mobility in Soil: Moderate to high mobility expected if spilled; best to prevent release outside controlled environments.
Waste Disposal: Collect solid or liquid waste in designated chemical containers for hazardous materials.
Methods of Disposal: Incineration at a licensed facility reduces risks linked to bioactivity.
Precautions: Do not flush down toilets or pour into drains.
Packaging: Contaminated packaging should undergo similar procedures as unused material, ideally disposed of through licensed chemical waste contractors.
UN Number: Not classified as dangerous for transport under most regulations.
Transportation Methods: Properly packaged containers decrease the risk of dust escape or spill.
Precautions During Transit: Avoid high temperatures, direct light, or physical damage to containers.
Classification: No listing in mainstream hazardous chemical registries like the US TSCA or European REACH database as of now, but it’s prudent to treat with the same care as other cytotoxic or laboratory chemicals.
Labeling: Clearly mark all containers with contents and hazard warnings.
Workplace Controls: Many institutions require special training or handling protocols for nucleoside analogs, ensuring only trained personnel handle even small amounts.
Policy Recommendations: Advocating for regular training on new chemicals and reviewing disposal methods helps reinforce safe habits and sustain a safer lab environment in the long term.
