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Product Name: 4-Nitrophenyl α-D-Glucopyranoside
CAS Number: 3767-28-0
Synonyms: p-Nitrophenyl-α-D-glucopyranoside, α-D-Glucopyranoside, 4-nitrophenyl
Recommended Use: Laboratory reagent, enzyme substrate
Manufacturer: Supplier details available upon request or from procurement
Emergency Contact Number: Refer to local jurisdiction emergency listing or manufacturer
GHS Classification: Not classified as a hazardous substance per current regulations, but dust and residue may irritate eyes, skin, and respiratory tract
Signal Word: Not required
Hazard Statements: May cause irritation to eyes, skin, and mucous membranes on prolonged or repeated exposure
Pictograms: None required based on hazard classification
Precautionary Statements: Avoid breathing dust, use appropriate protection to prevent contact with skin and eyes, maintain good workplace ventilation and hygiene
Other Hazards: May form dust clouds combustible under some conditions; avoid accumulation and sources of ignition
Chemical Identity: 4-Nitrophenyl α-D-Glucopyranoside
Chemical Formula: C12H15NO8
Molecular Weight: 317.25 g/mol
Concentration: >98% pure (as supplied by most major laboratories or chemical providers)
Impurities: Trace sugars, water, trace solvents (as per supplier spec), no additional ingredients that alter hazard classification
Inhalation: Move person to fresh air, seek medical attention if symptoms like coughing, choking, nausea develop, provide respiratory support if breathing difficult
Skin Contact: Thoroughly wash affected area with soap and water, remove contaminated clothing, seek medical advice if irritation persists
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and seek medical help if discomfort or redness persists
Ingestion: Rinse mouth with water, drink water for dilution, do not induce vomiting without medical direction, contact poison control if adverse effects occur
Most Important Symptoms/Effects: Irritation, redness, coughing, headache, nausea
Advice to Physicians: Treat symptomatically, provide supportive measures as needed
Suitable Extinguishing Media: Use CO2, dry chemical powder, alcohol-resistant foam, or water spray to control fire
Specific Hazards: May emit toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide upon combustion; dust may contribute to fire risk if dispersed in air
Special Protective Equipment for Firefighters: Wear full protective gear including self-contained breathing apparatus, isolate from sources of ignition, avoid inhalation of smoke and decomposition products
Advice for Firefighters: Approach from upwind, contain runoff water, avoid breathing vapors or fumes
Personal Precautions: Avoid dust formation, wear gloves, protective eyewear, dust mask or respirator as warranted, ensure adequate ventilation
Environmental Precautions: Prevent spill from entering sewers, soil, or waterways
Methods for Clean Up: Sweep up carefully using methods that minimize dust generation, place material in designated waste disposal container, wash area with water after removal, ventilate area thoroughly
Reference to Other Sections: See handling, exposure controls, and disposal sections for further details
Handling: Avoid contact with skin, eyes, and clothing, minimize dust generation and accumulation, work in well-ventilated area, use local exhaust ventilation as needed
Hygiene Practices: Wash hands thoroughly after handling, do not eat, drink, or smoke during use, remove contaminated clothing and protective equipment before entering eating areas
Storage Conditions: Store in tightly sealed original container, keep away from incompatible materials (strong oxidizers), store in cool, dry, well-ventilated place, protect from moisture and sources of ignition
Incompatibilities: Avoid contact with strong acids, bases, and oxidizing agents
Special Requirements: Store away from food and beverages, segregate from direct sunlight or high humidity
Engineering Controls: Use fume hood, local exhaust or general ventilation to control dust, monitor airborne concentrations if large quantities handled
Control Parameters: No occupational exposure limits established by OSHA, ACGIH, NIOSH, or other agencies for this compound
Personal Protective Equipment:
Gloves: Suitable nitrile or latex gloves
Eye/Face Protection: Safety glasses with side shields or goggles
Respiratory Protection: Dust mask or respirator if dust concentration is high
Skin and Body Protection: Laboratory coat, long sleeves, closed shoes
Environmental Exposure Controls: Avoid uncontrolled release to environment, contain spills using absorbent, prevent access to drains
Appearance: Pale yellow crystalline powder
Odor: None or faint, characteristic
Odor Threshold: Not established
pH (5% solution): Approximately neutral
Melting Point: 151-155 °C
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable for this solid
Evaporation Rate: Not relevant for non-volatile solid
Flammability: Not classified as flammable; dust may present explosion hazard in air
Vapor Pressure: Not measurable at ambient conditions
Vapor Density: Not applicable
Specific Gravity/Density: Approximately 1.6 g/cm³
Solubility: Soluble in water, limited solubility in ethanol
Partition Coefficient (log Kow): Not determined
Decomposition Temperature: >190 °C
Viscosity: Not applicable
Reactivity: Stable under recommended storage and handling conditions
Chemical Stability: Stable under ordinary laboratory conditions, avoid contact with incompatible substances
Possibility of Hazardous Reactions: Does not polymerize spontaneously
Conditions to Avoid: Extreme temperatures, moisture, sources of ignition, dust buildup
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide released on combustion or decomposition
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Not acutely toxic based on available data (no LD50 values established for humans); large doses may cause gastrointestinal or respiratory tract irritation if ingested or inhaled
Skin Corrosion/Irritation: May cause mild irritation on prolonged or repeated contact
Eye Damage/Irritation: Risk of redness, watering, and irritation
Respiratory or Skin Sensitization: No data indicating sensitization; possible mechanical irritation from dust
Germ Cell Mutagenicity: Not tested; no data indicating mutagenic potential under normal use
Carcinogenicity: Not listed by IARC, NTP, OSHA, or ACGIH as carcinogenic
Reproductive Toxicity: No data available; use good laboratory hygiene to minimize risk
Specific Target Organ Toxicity – Single Exposure: Not identified
Specific Target Organ Toxicity – Repeated Exposure: Not identified
Aspiration Hazard: Not classified
Symptoms of Exposure: Irritation, coughing, redness, possible nausea
Ecotoxicity: No detailed studies, but as a sugar-based aryl glycoside, it is expected to have low environmental toxicity, watch for possible chronic effects due to component nitrophenyl group presence
Persistence and Degradability: May biodegrade slowly in soil and aquatic systems, but specific rates not established
Bioaccumulative Potential: Not expected to bioaccumulate significantly due to water solubility and metabolism
Mobility in Soil: Readily miscible in water, can migrate in aqueous environment
Other Adverse Effects: Avoid uncontrolled release; collect and dispose of responsibly to prevent environmental contamination
Disposal Methods: Dispose of contents/container in accordance with local, regional, national, and international regulations; typically as laboratory chemical waste
Contaminated Packaging: Rinse thoroughly, dispose or recycle as per laboratory chemical packaging waste procedures
Special Precautions: Do not discharge into drains or the environment, prevent spread of dust, avoid landfill where possible, incinerate using approved chemical waste incineration process if available
UN Number: Not regulated for transport (non-dangerous good under ADR/RID, DOT, IMDG, IATA)
Proper Shipping Name: 4-Nitrophenyl α-D-Glucopyranoside
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: Not classified
Special Precautions for Transport: Protect from moisture, avoid excessive heat, keep packaging intact and properly labeled
Customs Tariff: Refer to relevant commodity code based on country regulations
U.S. Regulations: Not listed as a hazardous chemical under OSHA HCS, not listed as toxic substance under TSCA, not subject to SARA 302/304, CERCLA, SARA 313, or California Proposition 65
European Union: Not classified as hazardous according to Regulation (EC) No 1272/2008 (CLP/GHS Classified), not listed in Annex I of REACH
Other International Regulations: Not listed on the Canadian DSL/NDSL, Japanese ENCS, Australian AICS, or Korean ECL as controlled or hazardous, handle in accordance with applicable local, national, and international standards
Labelling Requirements: Use appropriate hazard and precautionary statements in workplace settings, provide adequate training for laboratory personnel
Workplace Control Information: Employer responsibility to ensure risk assessment and safety practices are current and in effect
