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4-Methyl-o-Phenylenediamine: A Deep Dive

Historical Development

Scientific progress turns up surprises, and 4-Methyl-o-phenylenediamine shows how chemistry quietly changes daily life. During the early-to-mid 20th century, organic chemists came across this compound as they searched for aromatic amines with tailor-made substitutions. Benzene ring modifications led to a whole class of methylated phenylenediamines, valued for their reactivity and range of applications. Lead researchers in both European and American chemical laboratories recognized how methylation altered both chemical behavior and safety profiles of existing aromatic derivatives, so demand picked up as the dyes and pharmaceuticals industries flourished. As a result, large companies invested in refining production techniques. Early patents document stepwise improvements, highlighting the competitive drive to boost yields and cut costs in synthesis. By the 1970s, chemical catalogues across the globe routinely featured this diamine, signaling its steady march from academic curiosity to industrial workhorse.

Product Overview

Buyers look for reliability and traceability, which pushes chemical suppliers to invest in careful quality assurance. On the bench, 4-Methyl-o-phenylenediamine stands out for its dual amine groups and methyl twist on a familiar aromatic backbone. Out in the field, chemists use it as both a starting point and a finishing touch for a host of products. Specialty dyes, polymer stabilizers, and pharmaceutical intermediates owe their existence in part to this molecule’s versatility. Its shelf life, ease of handling, and predictable reactivity help companies keep processes humming along. That consistency comes from decades of incremental improvement—not just in manufacturing, but in packaging, logistics, and regulatory compliance.

Physical & Chemical Properties

Take this compound in your hands and the sense cues become clear: light yellow to brown solid with a slight amine odor, solubility dancing between water and organic solvents. It melts at roughly 58–61°C and boils close to 267°C, traits that make it easy to manipulate in standard glassware. Vapor pressure remains modest at room temperature, so exposure risk is moderate if ventilation is working. With both ortho-substitution and a pendant methyl, it packs more resonance than its unsubstituted cousin. Infrared and NMR spectra demonstrate characteristic signals for aromatic and NH2 groups, so spectral identification rarely creates headaches. Chemists appreciate its stability under inert atmospheres and mild sensitivity to air, which means less product loss through oxidation.

Technical Specifications & Labeling

Customers demand specifics: purity above 98%, moisture content lower than 0.5%, and minimal trace ions, such as iron and chloride, that can skew reaction yields. Labels must feature CAS number 95-54-5, United Nations transport codes, standardized pictograms, and expiry dates. Packaging companies print hazard phrases to flag understood risks—acute toxicity, corrosivity, and environmental persistence. Batch numbers provide traceability in the event of recalls or regulatory spot checks. Safety data sheets drill down into PPE requirements, ventilation demands, and spill procedures, showing how companies balance operational needs with worker protection. Over time, both domestic and international standards agencies have tightened requirements, so modern documentation leaves little room for ambiguity.

Preparation Method

Chemists prepare 4-Methyl-o-phenylenediamine from p-toluidine by processes that involve nitration of the methyl-substituted benzene ring, followed by careful reduction. Hydrogenation with a palladium-on-carbon catalyst turns nitro groups into amines with good selectivity, especially at lower pressures. Small-scale operations occasionally use chemical reduction with iron powder and hydrochloric acid, though waste disposal from these traditional routes can complicate matters. European producers in the ‘90s started exploring biocatalytic pathways and more atom-economical reductions to cut down on toxic byproducts. Recrystallization from ethanol or water/ethanol mixtures delivers a solid product with tight purity controls. Each step requires precise temperature, pH, and agitation controls to stop unwanted tar formation—a common pitfall for aromatic diamines.

Chemical Reactions & Modifications

Once synthesized, 4-Methyl-o-phenylenediamine proves willing to react across a surprisingly broad spectrum. Both amine groups open the door to condensation, diazotization, and acylation. Mixing with acid chlorides or anhydrides produces tailored amides. Reactions with nitrous acid rapidly build diazonium salts—a key intermediate in azo dye production. Cross-coupling with aryl halides through modern palladium catalysis creates more complex aromatics. Devoted research groups have tinkered with N-methylation, oxidative coupling, and formation of Schiff bases, seeking new molecular tools with enhanced electronic behavior. Some processes use it as a building block in epoxy curing agents or stabilize polymers by trapping free radicals. Chemical libraries log dozens of derivative compounds, linking subtle tweaks in synthesis to wide shifts in reactivity and industrial demand.

Synonyms & Product Names

Catalogues around the world use slightly different names: 2-Amino-4-methylaniline, 4-Methylbenzene-1,2-diamine, or 1,2-Diamino-4-methylbenzene are common. Pharmaceutical intermediaries sometimes call it “p-Toluenediamine” (specifying positioning when clarity is needed), and older journals turn up synonyms like “Toluylene-2,3-diamine.” This jumble in naming often confuses young chemists, who learn to double-check CAS numbers and structural formulas before ordering, especially as regional dialects of chemical English persist. Reliable suppliers flag both traditional and IUPAC names, reducing the risk of cross-shipment and supporting safety compliance at the warehouse level.

Safety & Operational Standards

Experience handling aromatic amines shapes safety culture in both research and industry. 4-Methyl-o-phenylenediamine poses risks if inhaled, swallowed, or absorbed through the skin. Regulatory agencies treat it as an acute toxin, so gloves, goggles, and proper extraction ventilation become mandatory. Spills require neutralization with sodium bisulfite or similar agents, and contaminated surfaces need prompt cleaning with copious water. Waste streams containing this diamine must travel to licensed chemical destruction facilities. Industrial hygiene programs track airborne concentrations with personal dosimeter badges and periodic air sampling. Employee safety training now features real-world incident case studies, building awareness of accidental exposure symptoms: headaches, dizziness, and skin irritation. Laws in North America, Europe, and Asia have continuously updated permissible exposure limits (PELs), marking a broader trend towards stricter oversight in chemical management.

Application Area

Traditional users include dye manufacturers, where 4-Methyl-o-phenylenediamine helps forge azo and anthraquinone colorants. Hair dye chemistry draws on this compound too, since its oxidative coupling delivers the rich browns and blacks favored across cultures. Polymer scientists use it to fortify material skeletons, prolonging product life under UV stress and heat cycling. Some pharmaceutical developers leverage it as a core or side-chain modifier, aiming for better bioactivity in drug candidates. Analytical chemists know it as a colorimetric reagent, useful in quantifying trace metals. Research teams have even explored antioxidant and antimicrobial activities, opening doors to medical device coatings and water treatment additives. Each sector demands tailored grades, batch purity, and documentation—a sign of how one molecule can flow through many high-value markets.

Research & Development

Cutting-edge labs investigate both the classic chemistry and next-generation uses of 4-Methyl-o-phenylenediamine. Researchers model electron transfer rates, trying to predict and control color shifts in organic electronics. Surface scientists graft it onto nanoparticles, searching for selective biosensors and catalysts. University groups compete to design safer, greener ways to synthesize it, using flow chemistry and renewable starting materials. Recent journals highlight efforts to create hyper-functionalized derivatives for advanced polymers or solar energy capture. Funding agencies keep watch, hoping to balance economic growth with sustainability. Engineering teams refine process controls, cut emissions, and substitute hazardous solvents—all while keeping product performance high. These research pushes generate conference presentations, patent filings, and new safety guidelines—evidence that innovation in even a mature chemistry area never stands still.

Toxicity Research

This compound brings sharp lessons about risk and responsibility. Animal studies show hematological changes and organ toxicity from high exposure levels, with mutagenicity concerns raised by both in vivo and in vitro tests. Regulatory authorities recognize these red flags, treating 4-Methyl-o-phenylenediamine as a possible carcinogen and restricting its use in consumer-facing products in some applications. Chronic exposure links to methemoglobinemia, an illness marked by reduced oxygen-carrying capacity in blood. Toxicologists work on exposure models, mapping how the substance breaks down in the environment and in human bodies. Workers benefit from this cycle of vigilance, as companies introduce better ventilation, monitoring, and emergency spill response. Public health researchers still monitor long-term exposure data, looking for links between chemical misuse and disease clusters. Consumers trust regulatory agencies to set strong safety boundaries, creating pressure for substitute technology in sectors like cosmetics and food prep.

Future Prospects

As global industry shifts towards sustainability and green chemistry, 4-Methyl-o-phenylenediamine stands at a crossroads. Demand for safer colorants and polymer additives means both innovation and regulation will shape its role. If process chemists find ways to cut secondary waste and minimize exposure, industry could hold on to its economic benefits with lower environmental costs. Research into biodegradable derivatives, less toxic analogues, and alternative process chemistry will likely pick up speed, fueled by tighter rules and growing eco-consciousness. Up-and-coming applications—including organic semiconductors and specialty coatings—offer new markets if product stewardship keeps pace. The field rewards companies that take a proactive stance, investing in data transparency, lifecycle analysis, and zero-discharge manufacturing. As science and society push for better balance between industrial productivity and human health, 4-Methyl-o-phenylenediamine will keep forcing honest conversation between producers, regulators, and end users.




What is 4-Methyl-o-phenylenediamine used for?

What Makes 4-Methyl-o-phenylenediamine Useful?

4-Methyl-o-phenylenediamine shows up in more places than most people think. Many in the chemical industry know it as an important intermediate for several products. You’ll find it in the making of dyes, especially those used for fabric and leather. These dyes wouldn’t achieve the same sharp, lasting color without chemicals like 4-Methyl-o-phenylenediamine in their production lines. As someone who has worked in labs with industrial colorants, I know getting strong color takes more than mixing paint—it often depends on advanced chemistry and the right intermediates.

The same chemical can shift into completely different roles. Manufacturers use it when developing anti-corrosion agents. Pipes, tanks, tools, and vehicles benefit directly from this. These agents extend equipment life and reduce costs for everyone down the line. When you see fewer rusty city park benches or longer-lasting cars, it’s a sign the science is working behind the scenes. Years ago, I worked with a maintenance team that spent long hours sanding and repainting metal railings. Anti-corrosion methods cut that workload, letting folks focus elsewhere.

Research and Pharmaceuticals

Some research labs use 4-Methyl-o-phenylenediamine for synthesizing new pharmaceuticals and lab reagents. It helps shape experimental molecules, acting as a building block for more complicated structures. Researchers lean on its reactivity when they want to add exactly the right piece to a target drug. The process often means safer, more affordable medicines reach people who need them. Even the smallest advance in chemical synthesis can tip the scales toward a lower production price, so new therapies become more accessible.

Concerns and Handling

4-Methyl-o-phenylenediamine isn’t without its hazards. Handling it requires training and protective gear. Breathing fumes or direct skin contact poses health risks, including sensitization or more severe effects, depending on exposure. Factories and labs have to follow strict safety standards to keep workers safe. It’s rare to walk into a chemical facility and not see gloves, goggles, and specialized ventilation whenever this substance comes out. These safety measures show respect for the people doing the work, not just ticking off a checklist.

Environmental concerns pop up around production runoff and improper disposal. If it leaks into soil or water, it could threaten the health of animals and people nearby. Regulatory agencies have set up frameworks that force companies to review disposal methods and invest in better filtration. In my experience, even small improvements—a better seal on a tank, clearer warning labels—pay off by reducing both risk and community worry. The story of many chemicals is a trade-off between usefulness and responsibility, and this one is no different.

Looking Forward: Solutions and Adaptation

More companies look for safer alternatives or ways to reformulate processes so they rely less on toxic intermediates. Green chemistry, guided by the principle of reducing harm, keeps gaining ground. Developing substitute chemicals or recycling byproducts highlights a practical mindset. Chemical engineers, regulatory bodies, and community advocates all play a part in reducing risk without cutting off benefits. Careful research, improved workplace procedures, and smarter design help keep progress on the right track.

What are the safety precautions when handling 4-Methyl-o-phenylenediamine?

Staying Safe with 4-Methyl-o-phenylenediamine

Anyone who’s ever spent a day in a chemistry lab knows chemicals have personalities. Some demand respect, and 4-Methyl-o-phenylenediamine belongs in that group. It shows up in dyes, intermediates, and other industrial applications. It doesn’t look dangerous, but it can do harm, so routine and proper handling beats regret later.

Use Reliable Protection

Skin absorbs 4-Methyl-o-phenylenediamine fast. This chemical stings, itches, and leads to rashes in a hurry. Anyone handling it should put on nitrile gloves, not latex, since latex doesn’t always block everything. Lab coats and closed shoes matter, too. Plenty of workers think short sleeves and regular shoes “should be fine.” It’s not. One unnoticed splash, and you’ll remember the sting—a lesson you only want to learn once.

Goggles trump regular glasses. Misting and small droplets drift easily in a workspace. If it hits your eyes, the burn can be intense, with possible permanent damage. Goggles that seal well offer the kind of protection that means you get to keep your vision and peace of mind.

Indoor Air: Don’t Breathe This Stuff

Many overlook air quality in labs. It’s tempting to think a slightly open window fixes things, but fumes accumulate fast. 4-Methyl-o-phenylenediamine can irritate your lungs and nose. Fume hoods matter here, not as fancy add-ons, but as basic protection. I always check if the hood’s running before opening a bottle, because “good enough” ventilation doesn’t cut it. Chemical respirators work for spills or large-scale work. Respirators with organic vapor cartridges give a backup layer when the unexpected happens.

Personal Clean-Up Matters

Regular hand washing isn’t just about meals. It’s a core rule, something drilled into me after a painful rash in school that lasted a week. Soap—not just water—breaks down any clinging residue. Avoid touching your face, especially near your eyes or mouth. I keep my phone far from my workspace; surfaces collect residues, and taking even a quick message can mean transferring chemicals to skin.

Storage: Label Everything, Lock It Down

I once found a poorly labeled container in a shared fridge—no one knew what sat inside, and we lost a whole day cleaning up. Clear labels on all bottles, with the chemical’s name, date, and any hazard warnings, keep things safe. Store 4-Methyl-o-phenylenediamine out of sunlight, in a cool and dry spot. Separate it from acids and oxidizers; chemistry remembers every mistake. Locked cabinets, not open shelves, keep both curious hands and accidental bumps away.

Accident Response: Preparation Beats Panic

Emergency showers and eyewash stations belong within quick reach. Take ten seconds to rehearse the path—it pays off under stress. If a spill hits skin, plenty of water helps minimize damage. Once, during a rush to clean a bench, I almost skipped this step. Luckily, a colleague stopped me. That small pause prevented bigger trouble. Medical help matters after real exposure. Don’t try to “tough it out”—a professional can stop things from getting worse.

Building a Safety Culture

Facing risk comes with the territory in chemistry and manufacturing. Training transforms new workers from liabilities into assets. Clear rules, regular drills, and sharing close calls openly make accidents rare and recovery smooth. I’ve seen teams forget these habits once, convinced nothing bad happens “here.” Later, near misses served as reminders. Staying serious about safety is the best way to protect your team—and keep your mind on the work instead of worry.

What is the chemical structure of 4-Methyl-o-phenylenediamine?

The Building Blocks of 4-Methyl-o-phenylenediamine

Anyone who's ever set foot in a chemistry lab knows how the tiniest change—a single atom shifted, a lone methyl group attached—will change everything. That's the world of aromatic amines like 4-Methyl-o-phenylenediamine. The whole molecule can be summed up like this: a benzene ring, two amino groups sitting comfortably on carbon atoms right next to each other (the 'ortho' part), and a methyl group tacked on at position four. In chemical shorthand, you’d see it as 4-methyl-1,2-benzenediamine. Break it down: the benzene ring creates the structure's backbone, and the amino groups (each with two hydrogens and one nitrogen) are stuck to carbons one and two. That stray methyl group hangs off carbon four, just far enough to make the molecule stand out from the crowd.

Real-World Impact: Why This Structure Gets Attention

This isn't just a quirky molecule on a chalkboard. Structures like this turn up in dyes, developers, even some pharmaceutical compounds. Experience tells me that those two amino groups can act like Velcro, grabbing onto other molecules and creating strong, predictable reactions. Toss a methyl group into the mix, and you see even more interesting chemistry—sometimes for better, sometimes for worse. I’ve seen cases where just that little CH3 group changed a compound’s reactivity in the lab, made it more or less soluble, or even affected how dangerous it can be. Studies show that aromatic amines like these crop up in manufacturing and research settings, and some land under regulatory microscopes because of potential toxicity.

Health, Safety, and the Chemistry Lab

There’s a reason gloves and goggles hang on the wall. Aromatic diamines are known for being a little unpredictable health-wise. 4-Methyl-o-phenylenediamine, in particular, has the potential to act as an irritant, and there’s research tying certain related molecules to longer-term health risks. In the early days of figuring this out, nobody thought much of letting a few drops splash or inhaling dust. These days, regulatory agencies like OSHA and NIOSH track exposure closely, because these molecules can break down into compounds that react with DNA. Companies and labs keep a close watch on how much ends up in waste or the air. As a chemist, I always paid attention to the rumors: it’s not just about getting the reaction, it’s about staying healthy enough to write up the results.

Finding Solutions in Modern Chemistry

Research doesn’t stop at identification. Synthetic chemists are always looking for cleaner ways to use or replace molecules like this when developing dyes or materials. Safer alternatives come from careful tweaking: swapping out the methyl, shifting amino groups, or using completely different backbones. Green chemistry pushes us to design less toxic, more biodegradable compounds. Industry invests in air scrubbers and waste treatment systems to cut down environmental spills. In my own work, I found that using precise amounts and keeping reactions sealed helped avoid health headaches and waste costs.

Knowledge Is the Strongest Safety Tool

Being able to sketch the chemical structure of 4-Methyl-o-phenylenediamine from memory gives a lab tech or researcher an edge. Understanding those connections—where the methyl group lands, how close the amino groups hug each other—helps guide safe handling, smart research decisions, and compliance with regulations. Science moves forward fastest when those in the room recognize not just what a molecule does, but how its very shape makes all the difference.

How should 4-Methyl-o-phenylenediamine be stored?

Why Proper Storage Matters

Anyone who has worked with chemicals long enough knows the consequences of cutting corners. 4-Methyl-o-phenylenediamine, with its complex molecular structure, carries risks that stretch far beyond just safety goggles and gloves. I remember my first storage misstep. A mentor caught my mistake—one careless storage decision could have ruined half the lab’s collection and endangered everyone present. Safety at work asks for rigor and respect for the chemical itself, but it also calls for clear protocols and ethical responsibility.

Understanding the Chemical Profile

This compound doesn't behave like some of the benign powders crowding the back shelves of a cabinet. It reacts to air, light, and moisture. Exposure leads to degradation and sometimes, the formation of harmful byproducts. Worse yet, even slight inhalation or skin contact can trigger allergic reactions or worse. Research shows that aromatic amines, which include 4-Methyl-o-phenylenediamine, often present long-term health effects. The National Institute for Occupational Safety and Health (NIOSH) and the CDC both emphasize careful handling, and for good reason.

Smart Storage Steps Backed by Fact

Secure containers, airtight and built from materials that won’t react, form the first line of defense. Glass jars with PTFE-lined caps usually do the trick. Polyethylene and polypropylene also step up, since this chemical doesn’t corrode them. Keep storage spaces dark because intense light speeds up decomposition.

Temperature control isn’t just a recommendation; it’s a must-have. Anything above cool room temperature sparks unnecessary risks, raising volatility and escalating the chance of contamination. According to industrial hygiene standards, chemical refrigerators—not household ones—offer better insulation and containment for such compounds.

The Role of Segregation and Ventilation

Stacking chemicals by hazard class prevents accidents. Don’t put this aromatic amine near oxidizers or acids. Many laboratory mishaps involve incompatible chemicals stored inches apart. Strong ventilation in storage rooms also lessens vapor buildup. The Occupational Safety and Health Administration (OSHA) and American Chemical Society repeatedly outline these requirements, and with every update, their intent becomes clearer: keep people safe, keep chemicals stable.

Labeling and Inventory: Small Steps, Big Difference

Labels should withstand both handling and the passage of time. I lost years of research data after a single faded label, and have never skimped since. Put emergency instructions on every package. Train everyone—don’t assume even a seasoned technician remembers all rules. Digital inventories track expiration dates and storage conditions, minimizing mistakes and forgotten stockpiles.

Pushing for a Culture of Safety

Storing chemicals goes further than locking bottles behind doors. Leadership must prioritize clear protocols and foster a mindset that asks every lab worker to stay vigilant. Open dialogue after close calls, complete with honest reporting, can stop small issues from turning into crises. “Just a few minutes extra” isn’t a burden if it means no one suffers harm in the future. Safe storage practices extend from industry insiders to newcomers, shaping the entire landscape of responsible chemical management.

What are the potential health hazards of 4-Methyl-o-phenylenediamine?

Looking Beyond the Lab: A Closer Look at 4-Methyl-o-phenylenediamine

Step into any industrial lab or hair dye facility, and you might find shelves stacked with chemicals like 4-Methyl-o-phenylenediamine. It shows up in dyes, pigments, and sometimes as a chemical intermediate. The name sounds technical, but people working with it face real-world risks — especially if safety takes a back seat.

Why Health Experts Sound the Alarm

The potential hazards carry weight. Research by groups such as the International Agency for Research on Cancer (IARC) and the U.S. Environmental Protection Agency (EPA) points out serious dangers. The main concern comes from exposure through skin contact or inhalation of dust or fumes. Immediate reactions might include irritated skin, burning or watery eyes, and even breathing difficulties. Some workers report rashes or swelling after only minor contact — evidence that the body treats this chemical as a threat.

Long-Term Threats That Don’t Get Enough Attention

It’s easy to shrug off occasional coughing or mild discomfort, but the danger doesn’t end there. Repeated exposure carries risks that are far less obvious. Studies link regular contact with 4-Methyl-o-phenylenediamine to organ damage. Over months or years, the chemical can affect the liver and kidneys, sometimes in ways that don’t show symptoms until real damage takes place.

Research in toxicology journals also raises red flags about cancer risk. The chemical structure includes aromatic amines, a group known for connections to bladder cancer and other serious illnesses. Some workplace studies show workers in dye or chemical industries face above-average cancer rates. So, the issue runs deeper than itchy skin.

Real-World Impact and Stories from the Floor

Working in manufacturing for a couple years, I saw chemical safety corners skipped. Gloves break, masks hang loose, and ventilation equipment gets ignored during “just a quick task.” The attitude shifts once a coworker ends up in the nurse’s office or loses a week to unexplained illness. I spoke later with a chemist who described nerve pain and skin issues, then learned the root traced back to years handling aromatic amines without enough protection.

What Companies and Workers Can Do Differently

The science draws a clear picture: safer procedures lower risks. Secure gloves and proper goggles take top priority. Well-maintained exhaust systems in work areas keep harmful fumes from reaching lungs. Labels and warnings need to mean more than boxes checked for regulations — they should drive action. Effective training helps everyone on the floor understand what they’re up against, and why shortcuts backfire.

For managers, regular health monitoring and making substitution a real option give workers stronger protection. If a safer chemical substitute does the job, companies owe it to their teams to make the switch. Even small steps, like better handwashing stations or daily safety briefings, can cut down on avoidable exposure.

Choosing Awareness Over Habit

Taking these hazards seriously changes the game. Over time, people in my workplace who understood the risks started speaking up — not just for themselves, but for the next person who came along. Chemicals like 4-Methyl-o-phenylenediamine don’t explain the risks out loud. So, it falls to everyone in the process to learn, protect, and share what works for safety.

4-Methyl-o-phenylenediamine
Names
Preferred IUPAC name 4-methylbenzene-1,2-diamine
Other names 4-Methyl-1,2-benzenediamine
2-Amino-4-methylaniline
4-Methylbenzene-1,2-diamine
1,2-Diamino-4-methylbenzene
4-Toluenediamine
Pronunciation /ˈfɔːr ˈmɛθɪl oʊ fiːˈnaɪlˌiːnˌˈdaɪəˌmiːn/
Identifiers
CAS Number 95-80-7
Beilstein Reference 1209241
ChEBI CHEBI:17326
ChEMBL CHEMBL141220
ChemSpider 23910
DrugBank DB04268
ECHA InfoCard 05b4757e-ed6a-4de3-a551-2c3279c2a57d
EC Number 205-415-2
Gmelin Reference 84885
KEGG C08290
MeSH D014002
PubChem CID 86697
RTECS number SS7875000
UNII XF417D3HHL
UN number UN3437
Properties
Chemical formula C7H10N2
Molar mass 122.18 g/mol
Appearance off-white to light brown solid
Odor amine-like
Density 1.02 g/cm³
Solubility in water Slightly soluble
log P 0.18
Vapor pressure 0.01 hPa (25 °C)
Acidity (pKa) 13.4
Basicity (pKb) 7.68
Magnetic susceptibility (χ) -62.0×10⁻⁶ cm³/mol
Refractive index (nD) 1.642
Viscosity 28 cP (25 °C)
Dipole moment 1.62 D
Thermochemistry
Std molar entropy (S⦵298) 151.7 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) 83.3 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -3063 kJ/mol
Pharmacology
ATC code D08AX99
Hazards
Main hazards Suspected of causing genetic defects. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. Toxic to aquatic life with long lasting effects.
GHS labelling GHS02, GHS05, GHS06, GHS08
Pictograms GHS06,GHS08
Signal word Danger
Hazard statements H301 + H311 + H331: Toxic if swallowed, in contact with skin or if inhaled. H317: May cause an allergic skin reaction. H410: Very toxic to aquatic life with long lasting effects.
Precautionary statements P261, P280, P305+P351+P338, P310, P308+P313
NFPA 704 (fire diamond) 2-3-1
Flash point 93°C (199°F)
Autoignition temperature Autoignition temperature: 540°C (1004°F)
Lethal dose or concentration LD50 oral rat 237 mg/kg
LD50 (median dose) LD50 (median dose): 283 mg/kg (Rat, oral)
NIOSH WF0175000
PEL (Permissible) PEL: 0.1 mg/m3
REL (Recommended) REL (Recommended Exposure Limit) for 4-Methyl-o-phenylenediamine is: "0.1 mg/m3
IDLH (Immediate danger) IDLH: 20 mg/m³
Related compounds
Related compounds o-Phenylenediamine
4-Nitro-o-phenylenediamine
4-Methylcatechol