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Product Name: 4-Dimethylaminopyridine
CAS Number: 1122-58-3
Synonyms: DMAP, N,N-Dimethyl-4-pyridinamine
Recommended Use: Laboratory chemical, intermediate, catalyst, research applications
Manufacturer/Supplier: Refer to label or purchasing documentation for supplier identification
Emergency Contact: Call local poison control or chemical emergency number as listed on facility MSDS board
GHS Classification: Acute toxicity (oral, dermal, inhalation) Category 3, Skin irritation Category 2, Eye irritation Category 2A, Specific target organ toxicity (single exposure) Category 3
Label Elements: Danger; skull and crossbones pictogram; exclamation mark pictogram
Hazard Statements: Toxic if swallowed, in contact with skin or if inhaled. Causes skin and serious eye irritation. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust or fumes. Use protective gear. Wash skin thoroughly after handling. Only handle with adequate ventilation.
Other Hazards: Toxic effects may not show immediately. Dusts may form explosive mixtures with air.
Chemical Name: 4-Dimethylaminopyridine
CAS Number: 1122-58-3
Concentration: 98–100%
Molecular Formula: C7H10N2
Molecular Weight: 122.17 g/mol
Impurities/Additives: Not significant under normal manufacturing specifications
Inhalation: Move exposed individual to fresh air. If breathing is difficult, get medical attention right away. Provide oxygen if available and trained to administer.
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least 15 minutes. Seek medical advice for irritation, burns, or signs of poisoning.
Eye Contact: Rinse eyes carefully with plenty of water for at least 15 minutes, lifting upper and lower eyelids. Contact an ophthalmologist promptly.
Ingestion: Rinse mouth, avoid inducing vomiting. Seek medical help immediately. Never give anything by mouth to an unconscious person.
Notes for Doctors: Provide supportive care and treat symptoms. Observe for delayed toxicity effects.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide (CO2), foam, or water spray. Avoid spraying water directly into powder as runoff risk grows.
Specific Hazards: Possible emission of toxic fumes, including carbon oxides and nitrogen oxides. Fire may spread rapidly through dust clouds.
Protective Equipment: Wear self-contained breathing apparatus (SCBA) and full protective suit. Avoid inhaling combustion products.
Firefighting Instructions: Remove containers from fire area if safe. Douse with extinguishing agent from a safe distance. Avoid water runoff entering drains.
Personal Precautions: Evacuate unnecessary personnel. Wear appropriate protective equipment including gloves, goggles, and mask. Avoid breathing dust; prevent skin and eye contact.
Environmental Precautions: Block run-off to drains. Notify local authorities if material enters water or soil.
Methods for Clean Up: Sweep up spills gently to avoid dust formation, place in a labeled container for disposal. Ventilate spill area. Clean with moist towels or vacuum using HEPA filter.
Decontamination: Wash surfaces with plenty of soap and water after removal.
Handling Precautions: Handle in a chemical fume hood if possible. Wear PPE, avoid generating dust or aerosol. Never eat, drink, or smoke while using the product. Keep containers tightly closed when not in use.
Storage Conditions: Store in a cool, dry, well-ventilated area, away from sources of ignition or strong oxidizers and acids. Avoid humidity, keep container tightly sealed, store separately from incompatible chemicals.
Incompatible Materials: Strong acids, oxidizing agents, reducing agents
Storage Temperature: Ambient, away from heat and direct sunlight.
Exposure Limits: No established OSHA or ACGIH exposure limits. Use exposure control principles as for toxic organic powders.
Engineering Controls: Use local exhaust, chemical fume hoods, and process enclosures where possible.
Personal Protective Equipment: Eye/face protection (safety goggles, face shield), gloves (nitrile or neoprene), laboratory coat or apron, respiratory protection (N95 or higher if dust forms). Use hand protection in line with penetration time data provided by the supplier.
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing before entering eating areas.
Appearance: White to off-white crystalline powder
Odor: Faint amine-like odor
Odor Threshold: Not available
pH: Not available
Melting Point: 110–114°C (230–237°F)
Boiling Point: 263°C (505°F)
Flash Point: 113°C (235°F)
Evaporation Rate: Not determined
Flammability: May form combustible dust concentrations in air
Vapor Pressure: Very low at room temperature
Vapor Density: Not applicable
Solubility: Soluble in water, alcohol, ether, methanol, toluene
Partition Coefficient (log Kow): Not available
Viscosity: Not applicable
Decomposition Temperature: Not available
Chemical Stability: Stable under normal temperature and recommended storage.
Conditions to Avoid: Heat, humidity, direct sunlight, dust formation.
Incompatible Materials: Strong acids, strong oxidizing/reducing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, organic vapors.
Hazardous Polymerization: Not expected.
Acute Toxicity: Oral (rat) LD50: 188 mg/kg; Dermal (rabbit) LD50: 500 mg/kg. Inhalation toxicity info limited, expected to be moderately toxic.
Skin Corrosion/Irritation: Causes irritation, possible burns with prolonged or repeated exposure.
Serious Eye Damage/Irritation: Risk of eye damage if contact occurs.
Respiratory or Skin Sensitization: May cause sensitization with repeated or prolonged contact.
Germ Cell Mutagenicity: Data inadequate for classification.
Carcinogenicity: No indication of carcinogenicity from available data.
Reproductive Toxicity: Insufficient data to assess.
STOT (Single/Repeated Exposure): May cause organ irritation, drowsiness, dizziness, and affects to the nervous system.
Aspiration Hazard: Not classified.
Ecotoxicity: Serious water contaminant, very toxic to aquatic organisms; long-term effects possible.
Persistence and Degradability: Not readily biodegradable.
Bioaccumulative Potential: Potential for bioaccumulation not well characterized.
Mobility in Soil: Likely to move into groundwater due to high solubility.
Other Adverse Effects: Do not allow material to enter surface water or drains.
Disposal Methods: Dispose of in accordance with local, regional, or national hazardous waste regulations. Use licensed chemical waste contractor.
Unused Product: Treat as hazardous, avoid discharge into environment.
Contaminated Packaging: Rinse thoroughly, offer for recycling or landfill as permitted, following chemical decontamination.
Special Precautions: Wear PPE during all waste-handling activities, avoid dust and direct contact.
UN Number: UN2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (4-Dimethylaminopyridine)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Marine Pollutant: Yes
Special Precautions for Transport: Keep container tightly closed and in upright position, segregate from food and incompatible goods, transport in compliance with local and international rules.
OSHA (US): Covered under toxic chemicals; not listed as carcinogen by NTP, IARC, OSHA.
TSCA (US): Listed.
EU Regulations: REACH registration required. Classified as hazardous according to EC regulations.
Canada (DSL/NDSL): Listed on DSL.
Labeling Requirements: GHS/CLP labeling mandatory; see hazard identification for statements and pictograms.
Other Regulations: Subject to reporting under SARA Section 313 if used in significant quantities. Always check with local regulatory authority for additional restrictions or requirements.
