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Material Safety Data Sheet (MSDS) for 4-Catechin Hydrate

Identification

Product Name: 4-Catechin Hydrate
Synonyms: (+)-Catechin hydrate, Cianidanol hydrate, 2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol hydrate
CAS Number: 225937-10-0
Recommended Use: Research, laboratory analysis, industrial formulation
Manufacturer: Contact supplier or specific chemical provider for exact details
Emergency Contact: Refer to chemical supplier emergency line for direct response in spill or exposure events

Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Hazard Statements: May cause mild irritation to skin, eyes, or respiratory tract in sensitive individuals. Dust exposure can have local effects.
Pictograms: None required based on standard classifications
Signal Word: None
Precautionary Statements: Avoid generating dust; use in ventilated area; minimize direct contact

Composition / Information on Ingredients

Chemical Name: 4-Catechin Hydrate
Common Name: (+)-Catechin hydrate
Formula: C15H14O6 · xH2O (hydrate levels may vary)
Purity: 98% or higher in most analytical/research uses
Impurities/Additives: Traces of related polyphenols; water content varies (generally 1-4%)
EC Number: 207-443-4
Concentration: Single component, not a mixture

First Aid Measures

General Guidelines: Remove source of exposure; seek medical help if symptoms persist
Inhalation: Move person to fresh air; keep at rest; provide oxygen if difficulty in breathing
Skin Contact: Wash affected area with soap and water; remove contaminated clothing
Eye Contact: Rinse with water for at least 15 minutes, keep eyelids open
Ingestion: Rinse mouth thoroughly; drink water; seek medical attention if large quantities ingested or symptoms develop

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Media: Direct high-pressure water jets
Hazardous Combustion Products: Carbon oxides (CO, CO2) and other decomposition fumes
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective clothing
Firefighting Instructions: Remain upwind, use water spray to cool containers, prevent runoff into water systems

Accidental Release Measures

Personal Precautions: Avoid dust formation, ventilate area, use suitable PPE (gloves, goggles, dust mask)
Environmental Precautions: Prevent discharge into drains, surface water, or soil
Methods for Cleaning Up: Sweep up carefully without raising dust; place in labeled waste containers for disposal; clean spill site with water and detergent after material removal
Reference to Other Sections: Follow relevant PPE and disposal instructions in later sections; restrict area until cleanup completion

Handling and Storage

Handling: Work in areas with good ventilation; avoid inhaling particulate; keep away from food and drink
Storage: Store container tightly closed in a cool, dry, and well-ventilated place; keep away from direct sunlight, moisture, and sources of ignition
Precaution for Safe Handling: Practice good hygiene; wash hands after use and before eating or drinking; avoid contact with skin, eyes, and clothing

Exposure Controls and Personal Protection

Control Parameters: No established occupational exposure limits; use general dust safety guidance
Engineering Controls: Use fume hood or local ventilation for bulk handling
Personal Protection: Wear lab coat, chemical-resistant gloves (nitrile preferred), safety glasses or goggles; use dust mask or respirator if airborne dust present
Hygiene Measures: Wash hands and face thoroughly; do not eat, drink, or smoke around material
Environmental Exposure Control: Implement controls to prevent release to water and soil

Physical and Chemical Properties

Appearance: Off-white to beige crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Slight acidity in water
Melting Point/Freezing Point: Approximately 174-177°C (decomposes at higher temperatures)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Inert, not readily flammable
Vapor Pressure: Negligible at room temperature
Solubility: Partially soluble in water, more soluble in methanol and alcohol blends
Partition Coefficient (n-octanol/water): Not determined
Vapor Density: Not applicable
Relative Density: ~1.3 g/cm³
Decomposition Temperature: Above 200°C
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under normal storage conditions in dry, sealed containers
Conditions to Avoid: Excessive heat, strong oxidizing conditions, prolonged light exposure, moisture
Incompatible Materials: Strong oxidizers, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possible phenolic byproducts on decomposition

Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Low toxicity expected; large exposures may irritate mucous membranes
Chronic Effects: No long-term effects known from occupational exposure at standard levels
Symptoms: Potential respiratory irritation, mild gastrointestinal discomfort if consumed in quantity
Carcinogenicity: Not listed in major regulatory carcinogen lists (NTP, IARC, OSHA)
Mutagenicity: No evidence for mutagenic effects in standard testing
Reproductive Toxicity: None known; limited data available

Ecological Information

Aquatic Toxicity: Expected to have low to moderate toxicity to aquatic life
Persistence and Degradability: Compound can biodegrade in environment, though breakdown rates may vary
Bioaccumulative Potential: Low potential for bioaccumulation based on structure and water solubility
Mobility in Soil: Moderate mobility; soluble fraction may move into groundwater
Other Adverse Effects: No significant long-term environmental impacts documented; prudent use and disposal reduce overall ecological footprint

Disposal Considerations

Waste Treatment Methods: Collect and send material to licenced chemical waste processor; avoid landfill or direct waterway dumping
Packaging Disposal: Triple rinse and dispose of containers as hazardous chemical waste when possible
Regulatory Requirements: Adhere to regional, national, and local regulations concerning chemical and hazardous waste

Transport Information

UN Number: Not regulated for most land, sea, or air carriage
DOT/IMDG/IATA Classification: Not classified as a hazardous material
Special Precautions: Ship in well-sealed containers, avoid moisture contact during transit, use original packaging labels
Transport in Bulk: Not applicable

Regulatory Information

US Regulations: Not listed as a controlled or hazardous substance by SARA Title III, TSCA, or CERCLA
EU Regulations: Not classified as hazardous, not subject to REACH restrictions
International Inventories: May be listed on chemical inventories in countries such as Japan, Canada, Australia; consult supplier for details
Workplace Restrictions: Use in compliance with general occupational safety standards and laboratory rules; provide safety training where material is used regularly
Labeling Requirements: Standard chemical labeling, no specific hazard statements mandated under GHS for standard research use quantities