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Talking Safety: A Closer Look at 4'-Aminoacetophenone

Identification

Chemical Name: 4'-Aminoacetophenone
Synonyms: p-Aminoacetophenone, para-Aminoacetophenone
Chemical Formula: C8H9NO
Molecular Weight: 135.17 g/mol
Appearance: Pale yellow to beige powder, faint aromatic odor
CAS Number: 99-92-3

Hazard Identification

Physical State: Solid
Acute Hazards: Causes skin and eye irritation, harmful if swallowed or inhaled
Health Risks: May cause respiratory tract irritation, possible allergen for sensitive individuals
Fire Risks: Dust may form explosive mixtures with air
Risk Phrases: Irritant to eyes, skin, and respiratory system

Composition / Information on Ingredients

Main Ingredient: 4'-Aminoacetophenone (C8H9NO) — concentration typically 98% or higher in laboratory-grade powder
Impurities: Trace solvents, residual starting materials (often less than 2%)

First Aid Measures

Eye Contact: Rinse eyes gently with plenty of water for several minutes, remove any contact lenses
Skin Contact: Immediately wash skin with soap and water, remove contaminated clothing
Inhalation: Move outside to fresh air, loosen clothing, seek medical advice if coughing or breathing problems occur
Ingestion: Rinse mouth, avoid inducing vomiting, get medical attention if you feel unwell

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam
Fire Hazards: Dust may ignite if dispersed in air and exposed to an ignition source
Protective Equipment: Firefighters wear self-contained breathing apparatus and protective clothing
Thermal Decomposition Products: Releases toxic fumes of carbon oxides and nitrogen oxides when burned

Accidental Release Measures

Personal Precautions: Avoid breathing dust, use appropriate respirator, ventilate area
Spill Cleanup: Sweep up using tools that minimize dust, gather material in sealed container for disposal
Environmental Precautions: Prevent powder from reaching drains or natural water sources

Handling and Storage

Handling: Wear protective clothing, do not eat or drink nearby, avoid raising dust clouds
Storage: Keep in tightly closed containers, store in a cool, dry, well-ventilated place away from incompatible substances like strong oxidizers
Stability During Storage: Store at room temperature, keep away from light and moisture

Exposure Controls and Personal Protection

Engineering Controls: Work in fume hood or well-ventilated area
Protective Gear: Chemical safety goggles, nitrile gloves, laboratory coat
Respiratory Protection: Use NIOSH-approved dust mask if airborne particulate concentration increases
Hygiene Measures: Wash hands after handling, do not eat or smoke during use

Physical and Chemical Properties

Physical Form: Crystalline powder
Color: Pale yellow to beige
Melting Point: About 121–123°C
Boiling Point: Decomposes
Solubility: Slightly soluble in water, more soluble in organic solvents
Odor: Faint, aromatic
Vapor Pressure: Not significant at room temperature

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Sensitive to strong oxidizers, can undergo hazardous decomposition if heated excessively
Hazardous Decomposition: Produces toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides during combustion

Toxicological Information

Inhalation: May irritate nasal passages, coughing and discomfort possible if dust becomes airborne
Skin Contact: Prolonged contact can cause dryness or mild redness
Eye Contact: Causes irritation, redness, and tearing
Ingestion: Harmful; might result in nausea or abdominal pain
Chronic Exposure: Repeated or prolonged skin contact could eventually lead to sensitization in some people
Carcinogenicity: No classification due to lack of adequate data on carcinogenic potential

Ecological Information

Aquatic Toxicity: Possible toxic effects to aquatic life if significant amounts enter waterways
Persistence: Organic powder, not known to bioaccumulate, but may persist if released to the environment
Degradability: Expected to degrade slowly in soil or water under natural conditions

Disposal Considerations

Waste Disposal: Take unused powder and cleanup residues to a licensed chemical waste facility
Waste Code: No specific code without jurisdictional reference, treat as hazardous organic waste
Environmental Impact: Should not reach natural waters or municipal sewage

Transport Information

UN Number: Not classified as dangerous for transport under many systems, but must be packaged securely
Transportation Precautions: Seal containers tightly, keep away from food or animal feed
Hazard Labels: None required for most shipments, verify local regulations

Regulatory Information

Global Inventories: Found in several chemical inventories due to research and industrial uses
Restricted Use: Not usually restricted, observe local handling and disposal rules
Occupational Limits: No established exposure limits, guidance recommends minimizing dust in workplace
Safety Data: Follows chemical hygiene protocols laid out by national and international agencies