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Chemical Name: 3-(Trimethylsilyl)propionic-2,2,3,3-d4 Acid Sodium Salt
Common Synonyms: TSP-d4, Sodium salt of TSP-d4
Chemical Formula: C6H11D4NaO2Si
Relevant Use: This compound often finds a place in NMR (Nuclear Magnetic Resonance) applications, mainly as an internal reference standard, given its stable characteristics under controlled lab conditions and its minimal reactivity with routine solvents and solutes used in spectroscopy labs.
GHS Classification: Data reveal that this material carries a low direct hazard profile, but gaps remain for chronic exposure effects. Respiratory or skin irritation seems rare, but lack of population-level studies leaves uncertainty.
Pictograms: Few are warranted unless dust or aerosols arise during mishandling, in which case general irritant precautions make sense.
Signal Word: None, as confirmed by comparative surveys through chemical safety boards.
Precautionary Statements: Avoid blowing powder or mixing too rapidly. Repeated dermal contact still lacks thorough review over decades of use, so gloves are standard.
Main Substance: The bulk content is the titled acid sodium salt, which is stable and of interest for its isotopic labeling.
Purity: Reputable suppliers typically guarantee greater than 98 percent purity, and batch-tested results uphold reliability.
Impurities: Water traces, possibly minor hydrolysis products, are sometimes detected, though rarely at concentrations exceeding 1 percent.
Inhalation: Move any person affected by dust to fresh air. Breathing support, such as clean oxygen sources, may aid recovery if irritation happens.
Skin Contact: Remove particles right away using soap and water.
Eye Contact: Rinse gently and continuously with water for several minutes if discomfort occurs.
Ingestion: Drinking water may help, but medical consultation is wise if quantities larger than ordinary lab use are accidentally swallowed.
Notes for Medical Personnel: Standard protocols for chemical irritants fit, since severe toxicity evidence remains slim.
Suitable Extinguishing Media: Standard CO2, dry chemical powders, or foam products prove effective.
Special Hazards: Burning may cause generation of carbon oxides, silicon oxides, sodium compounds, all of which require modern fume control.
Protective Equipment for Firefighters: Self-contained breathing units and regular lab fire suits should be used. Combustion doesn’t trigger explosive vapor risks under reported storage conditions.
Personal Precautions: Avoid dust inhalation and direct skin contact. Eye protection is common sense.
Spill Clean-Up Methods: Collect material using disposable wipes or HEPA-filtered vacuums for fine particles. Wet down surfaces before sweeping to limit airborne spread.
Environmental Precautions: Contain entry into drains. Observing spill protocols from ISO-accredited journals keeps clean-up consistent.
Handling: Use in well-ventilated areas. Limit open air exposure to avoid product breakdown or contamination.
Storage: Closed amber bottles or sealed polypropylene containers extend shelf life. Oxygen and moisture sensitivity is mild, but storing in cool, dry rooms adds further protection and reduces caking seen in high-humidity climates.
Incompatibilities: Strong acids, oxidizers, and moisture extremes can degrade product over time based on stability studies across universities and manufacturers.
Engineering Controls: Fume hoods and local exhaust ventilation help limit exposure if powdering occurs. Routine weighing inside glove boxes isn’t usually called for, though high-throughput facilities have found them helpful.
Personal Protection: Nitrile gloves, standard lab glasses, and cotton lab coats suffice for the routine transfer and weighing operations. Cartridge respirators fit spill or clean-up scenarios.
Occupational Exposure Limits: Regulatory bodies have not declared exposure ceilings so far; practical lab exposure rarely approaches concern thresholds.
Appearance: Fine white to off-white powder
Pungency or Odor: Faint, not notable
Melting Point: Decomposition occurs above 200°C in most batches
Solubility: Highly soluble in water, insoluble in nonpolar organics
pH (aqueous solution): Mildly basic, typically above 7.5-8.5 in solution
Other Notables: Stable across a broad range of ordinary experimental conditions.
Chemical Stability: Bench tests reveal the compound stays stable under ambient temperature, free from light and moisture surges.
Conditions to Avoid: Extreme humidity and acidic environments degrade quality.
Hazardous Decomposition Products: Reports identify silicon oxide dust and simple sodium compounds after severe heating.
Acute Toxicity: No firm evidence of severe toxicity in animal models or accidental human exposures under controlled settings.
Irritation:** Minor irritation risk for eyes and skin comparable to other sodium salts.
Chronic Effects: Absence of long-term studies.
Carcinogenicity: No sources point to cancer risk under established guidelines.
Symptoms of Overexposure: Mild coughing or skin dryness at most.
Persistence and Degradability: Long-term stability in soil or water environments isn’t well documented, though released quantities stay low due to lab-scale use.
Bioaccumulation: Structure predicts low risk.
Aquatic Toxicity: Not flagged for significant aquatic harm by current research
Environmental Fate: Dilute releases likely break down over time; site-specific monitoring fits ongoing stewardship efforts.
Waste Treatment Methods: Avoid public water systems. Most labs deposit residues in sealed chemical waste drums slated for licensed disposal handlers.
Recycling or Recovery: Techniques are unestablished due to single-use focus in analytical science.
Not suited for landfill: Secure, sealed incineration by reputable chemical disposal facilities ensures containment.
UN Numbers or Classification: Not governed as a dangerous good in standard lab transport scenarios.
Packing Groups: Not listed as requiring specialized labeling or segregation beyond general chemical shipment protocols.
Special Precautions for Transport: Ship in tightly sealed containers with moisture barriers to ward off caking and clumping.
International Status: Most authorities register the compound as a non-hazardous substance.
Workplace Controls: Only standard chemical hygiene plans apply.
Reporting Requirements: Major agencies don’t list significant reporting or notification obligations for this compound at laboratory scale.
