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3-Chloroaniline: An Editorial Commentary

Tracing the Lineage of 3-Chloroaniline

With a past reaching back to the birth of modern organic chemistry, 3-chloroaniline shows how a single modification in a benzene ring changes the way an entire class of chemicals behave. Once early chemists understood the amine group’s knack for sparking chemical creativity, it didn’t take long for folks in labs around the world to start tinkering. Swap out a hydrogen with a chlorine on aniline and you end up with 3-chloroaniline—distinct in its actions and in the products it can help build. Its historical road connects improvements in dye production, innovations in pharmaceuticals, and a better understanding of aromatic chemistry. Anyone who has spent time in a chemistry lab knows the particular significance of chloroanilines, especially in fine chemical synthesis, pesticide design, and dye-making. You can witness its roots in those hands-on, industrial processes as chemists began relying on its versatility for practical innovation, long before digital systems or modern quality assurance teams dominated the conversation.

Product Overview: Real Utility in Chemistry

There’s nothing small about the practical reach of 3-chloroaniline. With just a tweak—a chlorine atom nestled at that third position—it sidesteps or alters reactivity, colors, and breakdown patterns in a way most chemists can spot in a reaction flask. The compound fits right in with the production of agricultural chemicals, pharmaceutical intermediates, dyes, and polymer building blocks. In pharmaceutical circles, it routinely acts as a foundation stone for synthesis routes that need both reliability and adaptability. On the plant side, 3-chloroaniline sits at the root of several herbicide and pesticide pathways. In dyes, its presence boosts color stability and affinity for fabrics. Each industry that touches aromatic amines has called upon this compound, counting on its well-documented performance and relative accessibility.

Physical and Chemical Traits That Matter

You won’t forget the smell of 3-chloroaniline after handling it—a sharp, almost medicinal edge to the aroma that lingers on gloves and lab coats. The chemical appears as pale yellow to brownish crystals. Weighing in at a molecular formula of C6H6ClN, it melts at temperatures just above 60°C and boils past 210°C, stubbornly holding its ground in most everyday conditions. Water only dissolves it to a small extent, but organic solvents like ethanol or ether take it up easily, which makes extraction and purification more straightforward. Those handling it need to respect its reactivity with oxidizers and its general gift for forming complex patterns in multi-step synthesis. I’ve always found that, compared to some other anilines, the presence of chlorine brings a certain stubbornness to reactivity—a trait both a blessing and a challenge when building chemical routes from scratch.

Technical Specifications and Labeling in the Real World

In my experience with chemical procurement and compliance, regulatory demands rarely stop at a simple identity confirmation. Labs and factories expecting 3-chloroaniline watch for standard labeling—purity levels, presence of free aniline, moisture content—because even minor deviations can throw an entire batch off track. Purity standards often top 98%, with specific calls on chloride and aniline by-products. Proper labeling reflects hazard classes for toxicity and potential environmental impact, especially with the increasing focus on safe storage and transport in international trade. Real-world labeling reflects all these realities: clear hazard symbols, batch identification, and no-nonsense handling advice so mistakes in fast-moving lab environments don’t turn into safety incidents.

Synthesizing 3-Chloroaniline: The Tried and the Tested

Preparation methods trace their origin to one unwavering strategy: introduce chlorine to the aniline ring and direct it toward the third carbon. Classic texts describe chlorination of aniline derivatives under controlled conditions, blocking positions to avoid unwanted by-products. I’ve walked through production units where this process still holds sway—using hydrochloric acid or other chlorinating agents, maintaining temperature, and actively controlling pH to guide the reaction away from side products. Another path starts with nitrobenzene, introduces a chlorine, then reduces the nitro group to an amine. Each method carries its quirks: chlorination yields need careful distillation, while reduction demands patience and careful post-reaction cleanup. Generations of chemists have argued over which sequence offers better environmental performance, but the core lesson remains: yield and selectivity win out as long as the process holds up under scale-up and industrial scrutiny.

How Chemical Reactions Shape Its Role

The laboratory value of 3-chloroaniline comes from the way that lone amine group throws itself into reactions. You’ll see it act as both a nucleophile and a foundation for countless modifications. Chemists often use it to build more complex aromatic amines, coupling it with sulfonic acids, acids, or alkyl groups to widen its sphere of use. The chlorine sits in place, waiting to become a springboard for further substitutions through nucleophilic aromatic substitution, setting the groundwork for the production of specialty dyes and pharmaceuticals. I’ve seen protocols built around this flexibility, letting a single starting material lead to an array of active molecules—especially in dye chemistry, where colorfastness and light stability depend on the right substitution pattern.

Names Matter: Synonyms and Product Designations

Trade and research worlds both use a string of synonyms; miss a label, and you’ll track down the wrong compound. “3-Chloroaniline” also goes by “m-chloroaniline,” “m-chloraniline,” and even numbers alone—such as “MCA.” Some older references point to its use as an intermediate under numbers or company-specific labels, but across journals, textbooks, and chemical inventories, these variants all aim at a single chemical structure. Clear communication on names cuts down on purchasing errors, saves time on regulatory filings, and keeps lab teams from repeating work.

Getting Safety and Operational Practice Right

In my years around chemical industries and teaching labs, the memory of old safety posters and later, far stricter guidebooks, stays fresh. 3-Chloroaniline carries recognised health risks. Direct skin or inhalation contact can trigger acute symptoms—irritation, headaches, respiratory discomfort. Long-term exposure highlights why safety routines get drilled into teams: the potential for chronic effects and environmental damage sits close to the surface. Strict storage in a cool, ventilated place reduces breakdown and spillage risk, and hands-on colleagues know never to gamble with gloves, eye protection, and local ventilation. Disposal routes rank high on the checklist, given wastewater and incineration regulations for aromatic amines. These controls aren’t just about checking boxes; each rule traces back to real mishaps or overlooked hazards in earlier decades.

What the Work Really Yields: Application Areas

Most days, industry turns to 3-chloroaniline because it works. In textiles, the world cares about color and longevity—that’s where this compound often makes its mark, either as a dye intermediate or as a stabilizing additive. Agrochemical developers rely on its presence in herbicide and fungicide production, counting on its effectiveness against specific weeds and pathogens. Medicines and specialty chemicals need starting materials that won’t cost a fortune or fail at the first scale-up; here too, 3-chloroaniline provides groundwork for creating compounds from antipyretics to local anesthetics. Polymer science benefits from its use in cross-linkers and as a building block for specialty resins. The span across these industries highlights its utility, with each user base keeping a close eye on pricing, purity, and regulatory expectations as supply chains shift.

Lab Notebooks Filled with Curiosity: Research and Development

Out in the research trenches, 3-chloroaniline gives synthetic chemists a testbed for developing new reaction methodologies. I’ve watched R&D teams in universities and companies experiment with greener chlorination agents and recycled catalysts, always asking if a synthesis can take one less step, cut down on solvent, or create less hazardous waste. In medicinal chemistry, investigators use 3-chloroaniline to build and screen new bioactive molecules, searching for next-generation antibiotics or cancer therapies. Polymer and dye research continues to probe how tiny changes in its structure can shift material properties or tune color absorption. Progress here doesn’t just mean more creative molecules; every marginal gain in synthesis efficiency or safety finds its way onto factory floors, driving incremental shifts in the larger industrial ecosystem.

Getting a Real Handle on Toxicity

Toxicity remains a major talking point. People working with aromatic amines know that keeping a respectful distance reduces both immediate and long-haul risks. 3-Chloroaniline, like its cousins, can cause real harm if mishandled. Test reports have shown hematological changes in exposed animals, and the compound’s breakdown products can carry equal or greater environmental burden. Waterborne releases, soil contamination, and even persistent residues in final products put added heat on those responsible for process controls and audit trails. Regulatory agencies scrutinize every new study, forcing producers and users to balance productivity with improved treatment protocols and exposure reduction. The chemistry community, in turn, keeps refining methods for safer handling, containment, and remediation—all moving toward a healthier workplace and planet.

Eyes Toward the Horizon: Future Prospects

Looking ahead, the future for 3-chloroaniline rests on new regulatory frameworks and the momentum for greener chemistry. The push towards lower-impact synthetic media, stricter discharge limits, and improved worker safety standards continues to shape how people design, produce, and dispose of this compound. Research partnerships between academia and industry seek cleaner synthesis routes, striving to substitute hazardous reagents and cut energy inputs. As demand for advanced pharmaceuticals and specialty chemicals grows, new derivatives and application streams will likely spring from this sturdy backbone. Economic pressures and the expanding scope of safety regulation ensure that only the most efficient, ethical, and well-controlled practices thrive in the marketplace. Those familiar with the compound’s long track record know that staying ahead calls for both technical improvements and broader stewardship—ensuring its renowned versatility matches up with today’s demands for sustainability and responsibility.




What are the main uses of 3-Chloroaniline?

What Makes 3-Chloroaniline Important?

Step into any conversation about chemical manufacturing, and 3-Chloroaniline always gets a mention. With its chlorinated benzene ring and an amino group, the compound packs enough punch to drive entire segments of the chemical industry. Over time, I've noticed how it threads itself into both industrial growth and everyday products, something you don’t always expect from a chemical that’s not too familiar to the general public.

Key Role in Agrochemical Production

A big chunk of 3-Chloroaniline finds its way into making herbicides and pesticides. Every time I’ve walked through large farming operations, somewhere in storage sits a stock of crop protection agents. Many of those products trace their origins to 3-Chloroaniline. This compound acts as a building block for some major herbicides used to control unwanted weeds. For example, propanil—an important rice field herbicide—relies on 3-Chloroaniline as a core intermediate. Without it, controlling weed growth would become much tougher and less efficient.

Supporting the Dye and Pigment Industry

Color in clothing and paper owes more to industrial chemistry than many realize. In textile mills, I’ve seen technicians mixing up batches of dye, prepping for huge production runs. Dyes and pigments based on azo compounds often start their journey with 3-Chloroaniline. Its chemistry allows for further functionalization, giving rise to a rainbow of shades that clothing brands depend on. The compound enables manufacturers to design complex colorants that last long and resist fading, which matters a lot for both quality and customer satisfaction.

Pharmaceutical Applications

On the health front, laboratories and drug manufacturers tap into 3-Chloroaniline for its versatility. Whenever pharmaceutical chemists look for ways to create new molecules, they often start with robust intermediates. This chemical fits the bill. It helps build certain analgesics, antipyretics, and even drugs with antimalarial functions. The streamlined synthesis cuts down production time, bringing needed medicines closer to those who count on them.

Varied Industrial Uses

Outside of the headline industries, 3-Chloroaniline also lands in the making of rubber processing chemicals and specialty polymers. Years ago, during a visit to a rubber compounding facility, I witnessed how small tweaks in chemical feedstocks translated into huge performance changes for the final product. In these plants, small amounts of 3-Chloroaniline stabilizes the products or enhances their reaction properties. It can also lend itself to specialty blends in coatings and adhesives, breathing new life into otherwise standard products.

Concerns and Looking Ahead

No discussion would feel right without mentioning the safety and environmental angles. Production and handling of 3-Chloroaniline calls for strong safety protocols. Exposure, if unguarded, carries health risks including toxicity and skin effects. Some research even suggests links to potential environmental hazards when residues escape into water systems. The solution lies in tighter process control, embracing green chemistry techniques, and pushing for continuous worker training. Companies have started investing in closed-loop systems, aiming to reuse or safely destroy wastes. Regulators keep a watchful eye and update guidelines as new studies emerge.

Striking a Balance

3-Chloroaniline delivers broad value, supporting food production, colorants, and essential medicines. The challenge comes in scaling its benefits while respecting worker health and environmental safeguards. By focusing on smart production methods and strict oversight, industries can keep drawing value from this key chemical—without letting its risks outweigh the rewards.

What are the safety precautions when handling 3-Chloroaniline?

Understanding 3-Chloroaniline and Its Risks

3-Chloroaniline pops up in more labs and chemical manufacturing spaces than most people might realize. It's a colorless to pale yellow liquid, and anyone working with dyes, pharmaceuticals, or agricultural chemicals has probably seen it on their shelf. The catch? Even skin-level contact with this stuff can be dangerous—it soaks in fast, burning skin, and even causing organ damage if you breathe too much in or swallow it by accident. There’s also a cancer risk after regular exposure.

Why Personal Protective Equipment Beats Luck

When I think back to my early days in a research lab, nobody skipped gloves, goggles, or lab coats when 3-Chloroaniline came out. Thick nitrile or rubber gloves—never the thin stuff you’d use for cleaning—made a key difference. Chemical splash goggles stop fumes and droplets from getting into your eyes, and a sturdy lab coat keeps the chemical off your skin and work clothes.

Face shields offer another layer if you’re pouring or mixing larger volumes. Avoid open-toed shoes or shorts; this isn’t a minor irritant you can ignore.

Ventilation Isn’t Optional

A solid fume hood changes the game. 3-Chloroaniline has vapors that can do real lung damage. It’s not just about comfort—good airflow drops the vapor concentration dramatically. Relying on regular room fans isn’t enough, since those only move air around without filtering. I’ve seen proper hoods with activated charcoal filters stop most airborne risks cold.

Chemical Storage Makes All the Difference

I’ve seen coworkers try the “out of sight, out of mind” trick, tucking nasty reagents on crowded shelves. For 3-Chloroaniline, separate metal cabinets intended for organics and poisons stand up to leaks and vapor buildup. Everything gets tightly closed, labeled clearly, and kept in containers with air-tight seals. Humidity and heat make this compound even more volatile, so climate control in storage rooms isn’t some luxury—it’s a must.

Spill and Exposure Response—Preparation Over Panic

No matter how careful you are, something slips or spills sooner or later. Lined trays under glassware and bottles keep drips from spreading. Absorbent pads and neutralizers need to be ready on shelves. For a spill, the top priority is getting the people out, not just grabbing the mop bucket. Once you’ve cleared the area, use proper PPE, ventilate, and tackle the mess following your site’s written procedures.

Accidents involving skin or eyes call for immediate flushing with water, not just a quick rinse. Any inhaled or swallowed chemical means contacting poison control right away; don’t try to tough it out.

Training and Real-World Practice

Knowing these steps only works if all staff, even new interns, can follow them from memory. Regular drills and clear signage keep the right safety habits top of mind. It’s easy to forget one time, but those shortcuts bring consequences.

Safer Substitutes and Less Risky Practices

Some companies have cut their use of 3-Chloroaniline down by switching to less hazardous substitutes. Reviewing each project for safer alternatives, limiting the amount handled, or automating transfers lowers the chance of exposure. Meanwhile, up-to-date safety data sheets posted near workstations reinforce why nobody should get casual around a chemical that causes as much trouble as this one.

Experience Teaches—But Only If You Pay Attention

After years working around industrial chemicals, I’ve learned that no checklist or rulebook replaces steady habits and respect for the risks. More than a few experienced lab techs have shared stories of momentary lapses that led to real injuries—and regret.

3-Chloroaniline isn’t something to take lightly. Every extra step in handling, storing, and responding pays for itself in peace of mind. It’s not paranoia—it’s common sense earned by those who’ve learned what can go wrong, and never want to see it again.

What is the molecular formula and structure of 3-Chloroaniline?

The Nuts and Bolts of 3-Chloroaniline

3-Chloroaniline isn’t a chemical that most folks think about during their daily routines, but its role in dyes, agrichemicals, and medicines can’t be denied. The backbone of this compound is rooted in its makeup. Its molecular formula is C6H6ClN. That means every molecule has six carbon atoms, six hydrogens, one chlorine, and one nitrogen atom. On paper, these numbers seem simple. In practice, they create a compound with many uses—one that deserves a closer look.

Mapping Out What This Molecule Looks Like

The shape of a molecule changes how it behaves. For 3-Chloroaniline, the structure starts with a benzene ring. That’s six carbon atoms in a loop, with alternating double bonds connecting them. Stick a chlorine atom on the third spot of the ring, count over two carbons from where you attach the amino group (NH2), and you’ve got the “3-chloro” part sorted out. The amino group sits on the first carbon. Chemists often call this setup a “meta” substitution. It’s not just about where each group attaches; the positions change everything from how the compound smells to how it reacts with other chemicals.

Digging Into Why Structure Matters

Back in college, my lab mentor used to hammer home the idea that structure controls function. In the case of 3-Chloroaniline, shifting that chlorine atom even one position would send you down a different chemical path. The molecule’s shape and the location of its key parts dictate what it reacts with, which byproducts it makes, and how safe or hazardous it becomes.

Some years ago, I worked with a group trying to make safer agricultural treatments. 3-Chloroaniline showed up in a batch of samples. Before using it, we had to know exactly where every atom sat—especially the chlorine. Getting that wrong could mean less effective results or unwanted side effects in the field. The “meta” position blocks certain reactions while allowing others, shaping the final product’s quality and safety.

What This Compound Means Outside the Lab

3-Chloroaniline’s importance stretches beyond chemistry circles. In factories, workers rely on strict safety protocols since exposure to aniline compounds can cause headaches, dizziness, or worse. Some governments keep a close eye on its use in manufacturing. Product safety isn’t just a box to check; it’s personal. Years back, a spill at a warehouse turned into a near disaster—local authorities quickly stepped in, traced the molecule’s signature, and responded to limit harm. If the compound had been a different isomer, cleanup plans would have shifted.

Accurate labeling and testing make a huge difference. Reliable chemical analysis confirms that the 3-chloro form is what’s on the shelf. Mistakes lead to recalls, legal trouble, or workplace risks.

Focusing on Solutions

Safer handling of 3-Chloroaniline needs both solid chemistry training and real-world awareness. Regular checks in plants, ongoing education for workers, and investments in more precise testing all help. Some companies now use green chemistry approaches, aiming to reduce the use or waste of potentially risky intermediates like this one. These steps bring better outcomes for the health of workers and consumers.

In the end, knowing a molecule’s shape and formula isn’t just a science problem—it’s critical for safety and progress. Each atom's place in 3-Chloroaniline shapes both the opportunities and responsibilities that come with using it.

How should 3-Chloroaniline be stored?

What’s at Stake With 3-Chloroaniline?

I’ve spent years around chemical labs and industrial supply rooms. Some products demand real respect. 3-Chloroaniline tops that list, mostly because this white-to-pale yellow liquid brings both opportunity and risks to the table. This stuff helps make dyes, drugs, and pesticides, but it also gives off harmful vapors and causes nasty skin burns. Keeping it locked up safely means looking after not just colleagues, but the environment and neighborhood too.

The Dangers People Face

Skin contact with 3-Chloroaniline can trigger blisters and lingering irritation. Breathing it in–even small amounts for a short time–brings headaches and nausea, possibly worse if caution goes out the window. The U.S. Environmental Protection Agency calls it a probable carcinogen. Left out in the open, this chemical can seep into soil or water, tainting everything downstream. No one wants that phone call from Hazmat, so attention to storage pays off.

Laying Down Smart Storage Rules

I used to work for an outfit where “just put it on the shelf” almost got us sued. Instead, make room for chemicals like 3-Chloroaniline in a flameproof, ventilated cabinet. Heat makes it break down and can ignite vapors, so keep it far from sunshine and machinery that throws sparks. Store in containers rated for strong chemicals–think glass or certain plastics that resist corrosion. Forget about rusty cans or old soda bottles.

Label Everything and Keep a Log

Small mistakes spark big emergencies. Every time I restocked our chemical storage, I checked labels twice, making sure the contents, date, and hazard class stood out. If people ignore half-rubbed-off stickers or skip the storage log, confusion follows. Clear, permanent labelling helps anyone, even a midnight inspector, know exactly what sits behind each door. A tidy logbook, digital or on paper, stops dangerous mixing and tells folks who last handled the stock. Accountability prevents more accidents than alarms ever could.

Shelter With Separation

Some staff want to throw everything together for “efficiency.” That’s fast, but foolish. Keep acids, bases, and oxidizers far away. I’ve watched a single leak set off a minor scare because incompatible chemicals shared a shelf. Separate incompatible substances using physical dividers or by keeping them in different cabinets. Chemistry has no patience for shortcuts in real life.

Temperature and Ventilation Matter

Basements might seem safe, but 3-Chloroaniline keeps better at stable, moderate temperatures, away from both damp and drafts. Good ventilation—ideally, mechanical fans with chemical filters—pulls toxic vapors out of the air. Leave it in a cramped, stuffy space, and the risk doesn’t just climb, it jumps. Fans also cut the odds of vapor buildup, which can otherwise lead to both health and fire hazards.

Keeping People Safe

Right gear changes everything. I always made sure we kept gloves, splash-proof goggles, and thick aprons close at hand anywhere we stored 3-Chloroaniline. Anyone handling the chemical received direct training from someone with experience, not just a printout. Routine safety checks, spill kits, and knowing the location of the eyewash station turned drills into life-saving habits. It’s one thing to read about safety, it’s another to make it a habit that sticks.

Final Thoughts on Responsibility

Cutting corners tempts some people—until there’s a spill, injury, or worse. Storing 3-Chloroaniline safely calls for a system, not just a spot on the shelf. With proper storage, strong labeling, attention to temperature and ventilation, and a steady focus on human safety, anyone can help keep risk down and work moving forward. Some chemicals demand our best, and this one’s at the top of that list.

What are the potential health hazards of 3-Chloroaniline exposure?

Invisible, but Impactful

Factories and labs handle all sorts of compounds, but 3-chloroaniline deserves a closer look. The stuff shows up in dyes, drugs, and even pesticides. In the real world, most people don’t know it’s around, but those who work near it or live close to industries using it might feel its effects most. Even without direct contact, leaks or improper disposal can send this chemical into water, soil, and air.

Workplace Hazards

Breathing 3-chloroaniline doesn’t take much for the body to begin feeling the consequences. Some folks might notice a headache or dizziness after breathing the fumes. Others talk about a metal-like taste or a soreness in the throat. Over time, repeated exposure presses harder. Skin contact quickly leads to irritation. In severe cases, the compound can pass through skin and enter the bloodstream. Reports show methemoglobinemia occurs—oxygen struggles to move through the body, and skin starts to look blue or gray.

Organ Damage on the Line

Animal studies and a handful of accidents offer warnings. Long-term exposure has clear links to kidney and liver damage. These organs play “clean-up crew” inside us, and 3-chloroaniline makes their jobs a lot harder. The International Agency for Research on Cancer hasn’t ruled it as a confirmed carcinogen for people, but the data on genetic changes in cells keeps toxicologists on their toes.

Risks Beyond the Factory Floor

Not just workers catch the fallout. Groundwater near manufacturing sites can get contaminated. Drinking from a tainted supply exposes families at home, not just in work clothes. Young children end up at greater risk by weight, since their bodies can absorb harmful stuff faster. Animal populations show warning signs too—fish and amphibians in polluted water take on chemical loads and suffer growth problems or die-offs.

What Makes This So Alarming

I spent half a decade using protective gear around chemical stocks, learning quick that accidents need only a moment. Shortcuts in handling or skipping clean-up—maybe that saves a little time, but the echo of those decisions can last years. One colleague spent a night in the ER after a splash, and nobody in my line of work calls fumes “inoffensive” anymore.

Solutions That Build Trust

Stronger ventilation systems cut poison from the air, and routine blood tests for workers catch problems early. Training isn’t just a legal checkmark; the people in harm’s way need real drills and reminders about emergency showers, gloves, and good hygiene on the job. Company waste disposal keeps neighbors safer—nobody enjoys hearing about illegal dumping in the news. Digital tracking from storage to transport adds an extra eye to stop leaks before they harm someone downstream.

Community Responsibility

Neighborhood groups push for regular checks on factories and transparent records about what gets released or stored nearby. Local clinics can offer testing for families worried about well water. Governments can set stricter exposure limits and hold companies accountable with tough inspections. Even small steps here save lives and help folks breathe a little easier—not just now, but for the generations living with today’s decisions.

3-Chloroaniline
Names
Preferred IUPAC name 3-chlorobenzenamine
Other names m-Chloroaniline
3-Chloraniline
MCA
m-Chloraminobenzene
3-chlorobenzenamine
Pronunciation /ˈklɔːroʊ.əˈnɪliːn/
Identifiers
CAS Number 108-42-9
3D model (JSmol) `3d:JSmol{"name":"3-Chloroaniline","mol":"NC1=CC(Cl)=CC=C1"}`
Beilstein Reference 1366121
ChEBI CHEBI:22732
ChEMBL CHEMBL16624
ChemSpider 1538
DrugBank DB01777
ECHA InfoCard 3-Chloroaniline (ECHA InfoCard): 100.003.313
EC Number 202-430-6
Gmelin Reference 82176
KEGG C01426
MeSH D002766
PubChem CID 7915
RTECS number BX9620000
UNII 27T8P5048Z
UN number 2810
Properties
Chemical formula C6H6ClN
Molar mass 127.56 g/mol
Appearance Colorless to yellow liquid
Odor ammonia-like
Density 1.203 g/mL at 25 °C(lit.)
Solubility in water Moderate
log P 1.87
Vapor pressure 0.042 mmHg (25°C)
Acidity (pKa) 3.98
Basicity (pKb) 8.90
Magnetic susceptibility (χ) -74.0 × 10⁻⁶ cm³/mol
Refractive index (nD) 1.618
Viscosity 1.22 mPa·s (25 °C)
Dipole moment 1.61 D
Thermochemistry
Std molar entropy (S⦵298) 203.7 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) 16.5 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -3330 kJ/mol
Hazards
Main hazards Harmful if swallowed, causes skin and eye irritation, may cause allergic skin reaction, suspected of causing cancer, toxic to aquatic life.
GHS labelling GHS02, GHS06, GHS08
Pictograms GHS06,GHS09
Signal word Danger
Hazard statements H301: Toxic if swallowed. H311: Toxic in contact with skin. H331: Toxic if inhaled. H411: Toxic to aquatic life with long lasting effects.
Precautionary statements P260, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310
NFPA 704 (fire diamond) 2-2-0
Flash point 113°C
Autoignition temperature 615 °C
Explosive limits Explosive limits: 2.7–12%
Lethal dose or concentration Lethal dose or concentration (LD50, oral, rat): 1300 mg/kg
LD50 (median dose) LD50 (median dose): 650 mg/kg (oral, rat)
NIOSH BW6650000
PEL (Permissible) Not established
REL (Recommended) 25 ppb
IDLH (Immediate danger) 50 ppm
Related compounds
Related compounds Aniline
2-Chloroaniline
4-Chloroaniline
Bromoaniline
Chloroacetanilide