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Product Name: 2-Thiobarbituric Acid
Chemical Formula: C4H4N2O2S
CAS Number: 504-17-6
Synonyms: 2-Thiobarbituric acid, TBA, 2-Sulfanylidenebarbituric acid
Recommended Use: Laboratory reagent, analytical chemistry applications, detection of malondialdehyde
Manufacturer Information: Supplier or manufacturer contact details printed on each container
Emergency Contact Phone: Local or national emergency information provided by supplier
Classification: Acute toxicity, eye irritation, specific target organ toxicity (oral exposure)
Hazard Pictograms: Exclamation mark (GHS07)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes eye and skin irritation; may cause respiratory irritation with prolonged or repeated exposure
Precautionary Statements: Wash hands thoroughly after handling, avoid eating or drinking during use, use only with adequate ventilation, avoid breathing dust or particles, wear protective equipment and eye/face protection
Chemical Identity: 2-Thiobarbituric Acid
Concentration: ≥98% (typical for laboratory use)
CAS Number: 504-17-6
Impurities: Typical preparations contain minor inert or nonreactive contaminants under 2% by weight
Formula: C4H4N2O2S
Skin Contact: Flush area with plenty of running water for a minimum of 15 minutes, remove contaminated clothing, seek medical attention if irritation develops
Eye Contact: Rinse eyes for at least 15 minutes under flowing water, lifting eyelids occasionally, consult an eye specialist if irritation persists
Inhalation: Move to fresh air, keep at rest in a position comfortable for breathing, provide oxygen or artificial respiration if indicated, get medical attention for symptoms including coughing, sore throat, or dizziness
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, drink several glasses of water, seek prompt medical advice
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Specific Hazards from Combustion: Sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide, toxic fumes may develop
Special Protective Equipment: Firefighters use positive pressure self-contained breathing apparatus and full protective clothing
Firefighting Procedures: Prevent runoff from entering drains, cool fire-exposed containers with water spray, evacuate area if large fire or explosion risk exists
Personal Precautions: Wear gloves, eye protection, disposable coveralls, avoid inhaling dust, ensure adequate ventilation
Environmental Precautions: Prevent spill from reaching sewers, surface water, or soil
Cleanup Methods: Sweep up and place waste in a suitable, labeled container for disposal, avoid generating dusty conditions, ventilate the area, rinse residue with water after picking up spilled material
Handling: Always handle in chemical fume hoods or well-ventilated spaces, avoid direct contact with skin, eyes, or clothing, wash thoroughly after handling, do not eat, drink, or smoke while using the material
Storage: Store containers tightly closed in a cool, dry area away from incompatible substances such as oxidizers, acids, or bases, protect from light, moisture, heat sources, and physical damage, label all storage containers clearly
Engineering Controls: Use local and/or general exhaust ventilation, chemical fume hood recommended
Personal Protection: Chemical-resistant gloves (nitrile or similar), safety goggles or face shields, laboratory coats or chemical aprons, dust masks or NIOSH-approved respirators for dust-generating work
Exposure Limits: No OSHA PEL or ACGIH TLV established, minimize exposure and practice routine monitoring
Hygiene Measures: Remove contaminated clothing immediately, wash hands, arms, and face after use, do not keep food or drink near work area
Appearance: Pale yellow to off-white crystalline powder
Odor: Odorless to faint sulfurous
Odor Threshold: Not applicable
Melting Point: 300°C (decomposes before melting)
Solubility: Slightly soluble in water (0.8 g/L at 25°C), more soluble in alcohol, acetone
Vapor Pressure: No measurable vapor at ambient conditions
pH: Not applicable (solid), slightly acidic in solution
Density: About 1.55 g/cm³ at 20°C
Boiling Point: Not applicable (decomposes on heating)
Flash Point: Not flammable under laboratory conditions
Partition Coefficient (Log Kow): Not determined
Chemical Stability: Remains stable at room temperature if kept away from moisture and light
Reactivity: Non-reactive under ordinary handling, can react with strong oxidizing agents, strong acids, or strong bases under controlled conditions, may degrade if exposed to prolonged heat or UV
Hazardous Decomposition Products: Carbon oxides, sulfur oxides, nitrogen oxides possible on burning
Incompatible Materials: Strong acids, strong bases, oxidizers
Polymerization: Does not undergo hazardous polymerization
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: May cause irritation to eyes, skin, mucous membranes, nausea, vomiting if swallowed, coughing or sore throat if inhaled
Chronic Effects: Prolonged or repeated exposure may affect liver or kidneys, slight risk of sensitization
Toxicity Data: LD50 (oral, rat): about 900 mg/kg, skin and inhalation LD50 not established
Carcinogenicity: Not listed by NTP, IARC, or OSHA as a carcinogen
Other Data: Not enough evidence for reproductive toxicity or teratogenic risk in humans, routine laboratory precautions recommended
Aquatic Toxicity: Low to moderate hazard for aquatic organisms, no significant bioaccumulation potential identified
Persistence and Degradability: Slowly biodegradable in the environment, breakdown time varies based on soil and water conditions
Mobility in Soil: Slightly mobile in moist soils, may leach if spilled in large amounts
Other Information: Keep out of waterways, prevent large scale release to any ecosystem, no known risk to the atmospheric environment
Waste Disposal Methods: Treat as hazardous laboratory chemical waste, use sealed containers, transfer for incineration or certified chemical waste landfill under local, state, and federal regulations
Container Disposal: Rinse thoroughly, triple rinse recommended, remove or deface labels, dispose of as chemical waste according to institutional protocols
Local Disposal Regulations: Follow local, regional, and national disposal guidance to minimize environmental contamination, avoid release to surface waters
UN Number: Not regulated under standard DOT, IATA, IMDG codes
Transport Hazard Class: Not classified as dangerous for transport
Packing Group: Not assigned
Environmental Hazards: Not considered marine pollutant
Special Precautions: Use sturdy, leak-proof containers, seal and label properly to avoid accidental exposure in transit, safeguard against spills or leaks during movement
TSCA Status: Listed on the U.S. Toxic Substances Control Act (TSCA) inventory
SARA Title III (Sections 302/304/313): Not subject to threshold reporting
OSHA Status: Not classified as a hazardous chemical under OSHA HazCom 2012
WHMIS (Canada): Not classified as controlled product
EU Regulation: Not listed as a substance of very high concern, meets REACH registration requirements
Other Regulations: Dispose and store following local, regional, and national laws, safety training recommended for laboratory workers and handlers, maintain up-to-date records of use and storage for inspection purposes
