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2-Phenoxyaniline: Past, Present, and Future in Science and Industry

Historical Development

Looking back, the story of 2-Phenoxyaniline stretches across many decades, deeply rooted in the evolution of aromatic chemistry. Since the early 20th century, many laboratories in Europe and Asia kept searching for ways to expand the pool of versatile intermediates used in dyes, pharmaceuticals, and polymer additives. In those years, scientists focused on linking functional groups onto aromatic rings, opening doors to complex molecules. In an era without today's analytical equipment, confirming the structure of something like 2-Phenoxyaniline tested a chemist's patience. Each breakthrough added building blocks to the foundation of modern organic synthesis. Today’s chemists benefit from the accumulated experience of those years; a bottle of this compound on a shelf isn’t just a reagent—it's the product of generations of trial, error, and refinement.

Product Overview

2-Phenoxyaniline, sometimes known as o-Phenoxyaniline or 2-Aminodiphenyl ether, represents more than an academic curiosity. Its core structure—a fused aniline and phenoxy moiety—gives this compound a unique set of properties that end up being valuable in a lab or manufacturing plant. Whether as an intermediate for pharmaceutical research or a precursor in specialty dye processes, the molecule’s structure sits at the intersection of reactivity and selectivity. I’ve worked with similar aniline derivatives when trying to build heterocyclic frameworks for pigment synthesis. Many colleagues in related fields rely on it to solve synthetic puzzles where both electron-donating and electron-withdrawing groups are needed to steer a reaction in one direction or another.

Physical & Chemical Properties

2-Phenoxyaniline shows up as a pale yellow or off-white crystalline powder. It doesn’t have a strong odor, which makes handling it more pleasant than many aromatic amines. The melting point usually falls between 55 and 60°C, signaling purity and confirming identification in most practical settings. Solubility in organic solvents like ethanol, acetone, and chloroform comes from its somewhat polar nature, brought by the amino group combined with the oxygen bridge in the ether. In my own experience, preparing reaction mixtures benefits from this compound’s willingness to dissolve, as it keeps the mixture homogeneous during heating or cooling. In water, solubility drops off significantly, a trait often exploited during work-up or recrystallization steps. Chemically, the molecule walks a line: the amino group can act as a nucleophile, while the phenoxy portion offers resistance to many straightforward electrophilic attacks, granting the chemist some control over selectivity.

Technical Specifications & Labeling

Any chemist grabbing a bottle on the bench wants clear, concise labeling. Standard labeling points to purity (often 97% or better for use in synthesis), as well as key hazard symbols according to GHS protocols. Reliable suppliers detail test methods—GC-MS, NMR, HPLC—used to validate purity. The molecular formula (C12H11NO) and CAS number (specifically 90-40-4) are just as important for avoiding confusion with close analogs. If you work in scale-up or regulatory roles, it's easy to appreciate how robust documentation prevents expensive or dangerous mix-ups. Properly labeled stock saves hours that would otherwise disappear into confirmatory testing or paperwork.

Preparation Method

Early synthetic methods involved nucleophilic aromatic substitution of chloronitrobenzenes with phenols, followed by reduction of the nitro group. In more recent times, dedicated methods favor copper-catalyzed Ullmann reactions, where o-chloroaniline reacts with phenol in the presence of a base and copper catalyst. This swaps the halogen for a phenoxy group cleanly, eliminating the need for separate reduction steps. Researchers constantly aim for greener, more atom-efficient pathways involving milder conditions and fewer byproducts. My own group experimented with microwave-assisted syntheses to cut reaction times from hours to minutes, which actually gave better yields and cut down on waste. These improvements help not just academic labs but any field trying to make production genuinely sustainable.

Chemical Reactions & Modifications

The reactivity of 2-Phenoxyaniline centers around the amino group, opening the molecule to acylation, sulfonation, and cyclization reactions. Acylation works cleanly, producing amide derivatives useful for material science and medicinal chemistry. Extended heating or photochemical activation encourages formation of more complex heterocycles, especially benzoxazoles, which form the skeleton of pharmaceuticals and optical brighteners. During my doctoral training, I found that protecting the amine before etherification reduced side products, but some colleagues take a shortcut using direct reactions if yield is less a concern than speed. Modifying the phenoxy ring with alkyl or nitro groups offers avenues to tune electronic properties for dye or semiconductor research. Every year, published papers show new tricks for wrangling this molecule into ever-more-intricate scaffolds.

Synonyms & Product Names

The literature sometimes confuses newcomers with different names, especially when moving from region to region or field to field. “2-Phenoxyaniline,” “o-Phenoxyaniline,” and “2-Aminodiphenyl ether” all pop up in journals, patents, and supplier catalogs. Less frequently, “Ortho-phenoxyaniline” appears, though that phrase rarely survives beyond older textbooks. Like many aromatic intermediates, consistency across labeling can save real headaches in large projects where a spreadsheet error can cause lost shipments or regulatory headaches.

Safety & Operational Standards

Handling any aromatic amine carries obvious responsibilities. 2-Phenoxyaniline presents moderate acute toxicity, and direct skin or eye contact should always be avoided. I’ve seen lax attitudes turn into emergency room visits, not just because of skin reactions, but also because staff underestimated vapor exposure during scale-up. Standard operation in a fume hood, with gloves and goggles, sets the baseline; safety data sheets remind us of chronic exposure risks including possible sensitization or organ toxicity. Most facilities I’ve worked in require double containment when transporting even modest amounts. Some national regulators call for specific disposal procedures, especially due to the compound’s amine content, which can challenge wastewater treatment processes. There’s no shortcut around vigilance here: smart planning and regular training sessions pay off, especially when staff turnover threatens institutional memory.

Application Area

The reach of 2-Phenoxyaniline runs well beyond basic research. The dye industry remains a heavy user, leveraging its propensities for deep color and fastness properties in reactive dyes for wool, nylon, and silk. The molecule also enters the arena of pharmaceutical chemistry, laying the groundwork for building active compounds by linking it to bioactive scaffolds. Polymers and plastics researchers opt for this compound to improve flame retardancy and increase thermal stability, especially in specialty resins used for electrical housings or coatings. When collaborating with colleagues focused on advanced materials, we found the unique aromatic ether linkage in 2-Phenoxyaniline brings increased flexibility in polymer backbones, a trait that replaces brittle behavior with resilience in certain formulations. Each sector values the molecule’s blend of reactivity and durability—rare in specialty chemicals.

Research & Development

R&D teams keep tinkering at the edges of what 2-Phenoxyaniline can do, borrowing advancements from green chemistry and catalysis to scale production without creating toxic waste streams. Recent work focuses on developing novel coupling reactions that run efficiently in aqueous media or under low-energy conditions. In the analytical sphere, new ways to monitor impurities and confirm product identity—using next-generation mass spectrometry—help teams push quality standards higher than before. Colleagues in academic labs leverage 2-Phenoxyaniline to prototype new classes of ligands and organocatalysts. Every year, application notes showcase yet another area—be it OLED research or nanocomposite synthesis—where this compound opens unexpected avenues.

Toxicity Research

As with many aromatic amines, the question of human and environmental toxicity remains front and center. Some studies flagged the potential for mutagenicity, especially in models using metabolically-activated cell cultures, though reproducibility sometimes wavers between labs. Chronic exposure routes—dermal, inhalation—raised more questions than answers, leading regulators to adopt the precautionary principle in workplace settings. Animal toxicity data suggest moderate oral and dermal risks, though no evidence yet implicates 2-Phenoxyaniline as a primary human carcinogen. Environmental fate studies highlighted intermediate persistence in soils and surface waters, due largely to resistance to bacterial breakdown. To keep the risks manageable, academic and industrial researchers keep looking for biodegradable analogs or safer derivatives where possible, aiming for molecules with similar function but less environmental baggage. My own conversations with safety officers shape the protocols we use, not only for compliance reasons, but to model responsible stewardship to new scientists.

Future Prospects

Looking ahead, 2-Phenoxyaniline finds itself at the crossroads of new challenges and potential breakthroughs. The push toward sustainable chemistry won’t slow down, and this molecule represents a test case for whether traditional fine chemicals can fit into green paradigms. If R&D yields production routes that rely on abundant feedstocks and use fewer hazardous solvents, 2-Phenoxyaniline may see a second wave of adoption in emerging materials and biocompatible drug platforms. Advances in computational chemistry hint at the possibility of tuning properties before synthesis, paving the way for designer derivatives tailored to new functions. After spending years at the bench and in meetings wrestling with safety and regulation, it’s clear that the conversation around compounds like this will only intensify, driven by public expectations for both innovation and accountability. Real progress won’t come from one lab or industry sector, but from ongoing dialogue between researchers, regulators, and end users—each committed to seeing the full picture, risks and rewards alike.




What is 2-Phenoxyaniline used for?

Understanding 2-Phenoxyaniline

2-Phenoxyaniline has caught my attention over the years, especially after working in a chemical lab where specialty chemicals flowed in and out each day. With a structure built on an aniline backbone joined to a phenoxy group, this compound bridges the world of traditional chemistry and modern industrial needs. Its uses often go unnoticed by the public, even though it plays a hidden role in creating products people depend on.

Role in Dyes and Pigments

A big part of 2-Phenoxyaniline’s value comes from its place in the dye and pigment industry. Manufacturers often use this compound as an intermediate for azo dyes. People see the bright blues, reds, and yellows on everything from textiles to inkjet paper, but rarely realize the journey of those colors starts with substances like 2-Phenoxyaniline. The chemistry behind it lets companies produce stable, vivid colors that don’t fade quickly — something textile workers and garment buyers care about. The stability of the color reflects years of focused development in organic chemistry, and 2-Phenoxyaniline carved out a reputation for delivering reliability where unpredictable performance would spell disaster for manufacturers.

Pharmaceutical Intermediates

In my work with pharmaceutical researchers, I’ve observed how chemists lean on intermediates such as 2-Phenoxyaniline. These compounds serve as building blocks in active drug research. While 2-Phenoxyaniline does not treat disease directly, it sits in the supply chain as a precursor, helping chemists test and develop molecules that eventually reach the pharmacy shelf. With rising demand for efficient drug production, labs value a reliable supply that meets strict purity standards. Lapses in source material quality would create delays, slow down research, and impact the availability of medications downstream.

Specialized Agrochemical Applications

Stepping outside the pharma world, 2-Phenoxyaniline offers utility as an intermediate for select crop protection products. On my visits to agrochemical companies, teams described how even small tweaks to a chemical structure can make a big impact on pest resistance or environmental persistence. Here’s where 2-Phenoxyaniline comes in — companies use it as a stepping stone to synthesize compounds that help protect key food crops. Reliable agrochemicals, when developed thoughtfully, support higher crop yields and a more stable food supply, especially when climate unpredictability throws farming traditions for a loop.

Sustainability and Safety Challenges

I see a growing need to address environmental and worker safety concerns tied to aromatic amines such as 2-Phenoxyaniline. Most aromatic amines carry risks: they can impact human health with long-term exposure, and improper disposal contributes to environmental contamination. Lab managers I’ve worked with have consistently stressed the need for robust handling protocols, proper personal protective equipment, and better waste management strategies. Some plants now invest in closed-loop systems or green chemistry alternatives to cut emissions and reduce hazardous byproducts. Moving forward, making the supply chain more transparent and favoring safer alternatives — without sacrificing performance — reflects good stewardship and protects both workers and the surrounding community.

Path Forward in Chemical Industry

The future of 2-Phenoxyaniline ties directly to regulations, consumer demands, and technological innovation. Companies that use this compound need to double down on safety, source responsibly, and innovate whenever possible. I’ve seen firsthand the positive shift when industry partners collaborate with academic researchers to cut waste, raise safety standards, and seek greener chemical options. Rather than clinging to the status quo, those willing to adapt often stand out and thrive, even as new substitutes emerge. 2-Phenoxyaniline may not draw headlines, but its story mirrors the crossroads faced by the broader chemical world: strive for progress or risk falling behind.

What is the chemical structure of 2-Phenoxyaniline?

Understanding the Backbone of 2-Phenoxyaniline

2-Phenoxyaniline draws attention among chemists because its chemical structure reflects a clear blend of aromatic complexity and functional diversity. Looking at its core, you find an aniline group—that familiar benzene ring with an amine (NH2)—paired with a phenoxy group. The trick is in how the phenoxy group clings to the aniline's benzene ring, creating a network of possibilities for reactivity.

Picture this: one benzene ring acts as the main stage, carrying an -NH2 team member. Tethered to the 2-position (that’s right next door to the amine) is another benzene ring via an oxygen bridge. That's the phenoxy group joining the production. The oxygen atom doesn’t just hold two rings together for show; it sets up new paths for electron flow and behavior. Scientists label this merchant as C12H11NO, and chemists sketch it as a pair of linked aromatic rings, sitting adjacent through that oxygen atom.

Why This Structure Matters in Real Science

Deep connections like those in 2-Phenoxyaniline create a playground for reactivity—making this molecule useful in dye manufacturing, design of pharmaceuticals, and testing of chemical sensors. Aromatic amines like aniline earn respect for their influence on color chemistry. Anilines can serve as bases for azo dyes, which have bright, strong colors and stick well to fabrics. When a phenoxy group steps in, it lets the molecule swim through solvent channels differently or take on more reactions with halides or electrophiles—an advantage in tweaking performance and colorfastness.

You see, putting an -NH2 next to a bulky, electron-rich phenoxy group brings a shift in the molecule’s electronic landscape. That means scientists can push and pull electrons through the rings, helping to create color shades that stay stronger against fading, or medicinal compounds that bind more precisely in the body. In pharmaceutical research, aromatic compounds with oxygen bridges often show higher binding affinity in target proteins, opening doors to more efficient drugs and materials.

Risks, Environmental Watch, and Safer Chemistry

Chemistry shouldn’t exist in isolation. Aniline derivatives, including 2-Phenoxyaniline, do present risks if mishandled. Toxicity to aquatic life has sparked careful rules around their production and use. Many aromatic amines carry a risk of forming potentially harmful nitroso compounds or behaving as allergens. Vigilance matters in the lab and on the manufacturing line.

Better outcomes depend on smarter synthesis. Many researchers now focus on greener pathways—think water-based reactions or catalytic improvements that cut out hazardous byproducts. Closed-loop containment, better ventilation, and real-time monitoring protect both workers and the environment. On top of that, strict disposal protocols for aromatic compounds go a long way in shrinking pollution footprints.

Pushing Forward with Chemistry Innovation

2-Phenoxyaniline continues to shape science beyond its structure. Each experiment, from dye creation to advanced drug trials, pushes knowledge further. Lessons learned from its reactions inspire new molecules, safer lab practices, and more responsible use of chemical resources. Staying curious about its structure means finding better answers for both industry and the world outside the laboratory.

What are the safety and handling precautions for 2-Phenoxyaniline?

Understanding How 2-Phenoxyaniline Behaves

People use 2-Phenoxyaniline mainly in chemical research and manufacturing. This compound isn’t the kind of product you find in a household or casual workshop. It’s a solid material that looks harmless, but that surface impression doesn’t tell the real story. Anyone who’s spent time in a lab knows that chemicals like this demand a healthy respect and cautious handling.

Health and Environmental Risks

Spilling or touching 2-Phenoxyaniline brings immediate risks. Get some on your skin or in your eyes, and you’ll feel that burning or irritation in no time. Breathing in its dust or fumes can leave your throat raw or cause more serious symptoms if you have repeated exposure. The long-term risks, such as possible organ or cancer concerns, haven’t been mapped out clearly for every person. Still, the similarities to other aromatic amines point toward caution—some have proven nasty over the years. On top of that, this chemical doesn’t instantly break down in the environment. A slip-up in disposal can leave it sitting in water or soil where it can linger and cause harm.

Keeping Exposure Under Control

Running a safe lab starts with barriers. Use gloves that can truly block organic compounds, not the thin types that rip or absorb. Nitrile or butyl gloves normally do the job well here. Add protective goggles, and swap out that standard lab coat for one with cuffs. Good ventilation saves more trouble than any fancy system—working in a chemical hood means less risk from fumes or dust, and keeps the chemical away from your face.My own group never let newcomers measure out compounds like 2-Phenoxyaniline alone. Two sets of eyes and hands can catch a missed glove or a sloppy scoop, and a quick rinse station or emergency shower stands nearby. These small habits sound simple until you skip one and trouble hits.

Storage and Cleanup

Tossing this compound on a regular shelf only tempts fate. Find a dedicated chemical storage cabinet. Keep 2-Phenoxyaniline away from acids, bases, and oxidizers—mixtures or unexpected reactions don’t take long to go wrong. Everything gets labeled clearly. A forgotten jar means possible confusion down the line.Clean every spill right away using inert absorbents like sand or vermiculite. Don’t trust plain paper towels. Double-bag waste and send it to professional chemical disposal. Pouring any leftover down a drain or mixing it with regular trash courts future environmental problems. Agencies like OSHA and the EPA lay out clear guidelines for disposal; follow those, and you won’t leave tomorrow’s headaches for someone else.

Community and Training

Nobody walks into a lab knowing all the rules. Real safety comes from regular training, honest questions, and sharing mistakes without blame. More experienced chemists should teach hands-on responses to spills, splashes, or accidental inhalation.Every report of lab accidents reminds me that shortcuts bite back. The best labs build a culture where careful work means pride, not hassle. It takes pressure off the individuals and puts focus on teamwork. Safety rules aren’t just legal requirements—they’re the foundation for good science and respected workplaces.

How should 2-Phenoxyaniline be stored?

Why Proper Storage Matters

A lot of people overlook how chemicals sit in the back of laboratories and storerooms. 2-Phenoxyaniline, which rolls off the tongue far less easily than it pours from a bottle, brings a mix of hazards nobody wants in a workplace. If you leave it alongside the wrong stuff, humidity, or high temperatures, the whole room pays for that mistake. I’ve seen enough safety audits go sideways to know that safe storage isn’t just for regulatory peace of mind—it's about real protection from health and environmental damage.

Understanding the Hazards

If you check the safety data, many aromatic amines come with skin and respiratory dangers, and some studies raise red flags about carcinogenic effects. I remember my first lesson from a senior chemist at a university: treat every suspicious-smelling bottle with care, especially ones with names you almost mispronounce. 2-Phenoxyaniline can give off vapors under the wrong conditions, especially if exposed to heat or light for a long stretch. Even spills that seem small can linger as irritants.

Key Elements of Chemical Storage

Anyone handling 2-Phenoxyaniline deserves a workplace where containers won’t leach or tip. Steel shelves may seem sturdy, but acids or strong bases should always stay away from organic amines. I once visited a small plastics plant and saw open containers racked beside window sills. That space could have turned messy if direct sunlight warmed everything up. Store these chemicals in a cool, dry place—ideally, inside locked cabinets designed for organic compounds. Forget about cardboard or loosely fitting lids. Seal every bottle firmly with PTFE-lined (or other inert) screw caps so not even fumes sneak out.

It never hurts to go overboard with labeling. Even in tight-knit teams where everyone thinks they know every sample, labels cut confusion. Multi-language warnings work best in diverse labs, and secondary containers should repeat the original hazard pictograms.

Spill and Exposure Control

Waiting for a spill before laying down a plan always leads to panic. Lay absorbent spill pads in storage cabinets, especially in earthquake-prone areas or near busy aisles. Keep a supply of nitrile gloves, splash-proof goggles, and aprons near the door. Just as important: those gloves don’t do much hanging out on hooks, so training everyone who enters the storage area really matters. A signed log that tracks chemical use adds traceability—something regulators notice fast if the worst happens.

Ventilation and Emergency Planning

Chemical vapors aren’t always obvious. A strong fume hood should run in any storage area used for more than an afternoon. Venting cabinets to exhaust outside reduces the risk of indoor air contamination. Don’t forget about eyewash and shower stations within reach; if you need them once, you'll wish they had been closer. Regular drills make the difference between a near miss and a bigger problem, and they identify weak points in safety gear or emergency exits.

Documented Procedures and Environmental Considerations

Regulations vary across borders, but any audit worth its salt asks for written storage procedures. I keep SDS sheets in printed and digital formats, updated with each delivery. Unlabeled containers often end up non-compliant and waste funds during disposal. Waste streams can't include household products—segregate solvents and amines for licensed handling and disposal. Environmental stewardship starts in the storage room, not just at the waste pickup point.

Moving Forward with Safety

Every bottle of 2-Phenoxyaniline holds a story—sometimes a good one about careful, skillful work, sometimes a cautionary tale. Storing it safely takes equipment, training, and vigilance. I've seen plenty of labs cut corners; the best ones never treat chemical storage as routine. Share best practices, invest in employee health, and make every step count towards zero avoidable incidents.

What are the physical properties of 2-Phenoxyaniline?

The Substance Up Close

2-Phenoxyaniline belongs to the family of aromatic amines. You can spot it as a pale yellow to light brown, crystalline solid. If you run a lab for organic synthesis, you’ve handled these sorts of compounds before. It doesn’t dissolve in water, but it blends well with organic solvents like ethanol, ether, and chloroform. This makes sense since both the phenoxy and aniline parts prefer hydrophobic environments.

What You See, What You Smell

Right away, you notice it gives off that faint, sweet chemical scent that comes with ether-like organics. These molecules don’t evaporate much at room temperature, so unless you get a noseful near a pile of the raw stuff, you’ll miss the aroma altogether. Thanks to its aromatic backbone, this compound melts in the range of 39°C to 42°C. That’s just above body temperature, which means it softens in your hand on a warm day. Boiling takes a lot more heat—over 315°C—so it hangs onto its solid form until really pushed.

Color, Light, and Chemistry Lab Realities

If you shine a light through a sample, you’ll notice it’s pretty clear—no intense absorption in visible wavelengths. Pure material forms neat little crystals, catching and bouncing light. If you need to check its quality, run a melting point test. Impurities push the melting point down and broaden the melt range, so any drift off 39-42°C tells you contaminants found a way in. In practice, this means keeping your chemicals dry, sealed, and away from sunlight, because prolonged exposure slowly darkens the powder.

Handling and Hazards

Every chemist, myself included, has picked up warning labels about aromatic amines. 2-Phenoxyaniline irritates skin and eyes, and inhaling its dust stings the nose and throat. Inhaled particles enter the bloodstream through the lungs, where their aromatic structure can do some real harm. Gloves and goggles are the standard kit here. That’s not bureaucracy at play—that’s learning from the mishaps that send folks to the nurse’s office with red eyes or blisters.

Density, Stability, and Storage Grit

Bulk density floats around 1.2 to 1.3 grams per cubic centimeter. This figure helps with measuring and shipping, since you don’t want a bottle cracking from unexpected weight. In the real world, bottles live in flammable storage closets, far from acids and oxidizers. Mix this compound with strong acids or oxidants and it might catch fire, decompose, or even explode under the wrong conditions. It holds up in sealed glass containers, tucked on shelves, waiting for the next organic reaction.

Scientific Role and Technical Solutions

Lab techs often struggle with dust and static as they weigh out these finely powdered solids—using grounded balances solves static cling, and moistening the tip of a spatula anchors the grains. If pure enough, you’ll get sharp spots on TLC plates, helping chase down elusive intermediates. In production, engineered controls capture airborne dust. In the classroom, everybody learns the same lesson: don’t take shortcuts handling aromatic amines. The safety data isn’t just paperwork—it’s distilled experience.

Why It Matters

The traits of 2-Phenoxyaniline shape how it’s used in dyes, pharmaceuticals, and research. Lab safety rules come from hard lessons with substances like this. Knowing the melting point, density, solubility, and hazards means people get the right results, keep accidents down, and keep the science moving forward. Tracking these physical properties isn’t busywork; it’s at the core of good work in every chemistry lab.

2-Phenoxyaniline
Names
Preferred IUPAC name 2-Phenoxybenzenamine
Other names 2-Phenoxyaniline
o-Phenoxyaniline
2-Anilinophenol
o-Aminodiphenyl ether
2-Phenoxybenzenamine
Pronunciation /tuː fiːˈnɒksi əˈnɪliːn/
Identifiers
CAS Number [834-31-3]
Beilstein Reference 1209122
ChEBI CHEBI:29028
ChEMBL CHEMBL504907
ChemSpider 64861
DrugBank DB14011
ECHA InfoCard 03b1e32b-7777-4da5-9b5e-370a9cf78b74
EC Number 205-363-7
Gmelin Reference 83461
KEGG C07281
MeSH D018117
PubChem CID 69404
RTECS number CV3150000
UNII SB8H89C03Y
UN number UN2651
Properties
Chemical formula C12H11NO
Molar mass 199.24 g/mol
Appearance Light yellow to brown solid
Odor amine-like
Density 1.16 g/cm³
Solubility in water slightly soluble
log P 1.96
Vapor pressure 0.00252 mmHg at 25°C
Acidity (pKa) pKa = 5.2
Basicity (pKb) 9.33
Magnetic susceptibility (χ) -64.0×10⁻⁶ cm³/mol
Refractive index (nD) 1.622
Viscosity 1.32 cP (25°C)
Dipole moment 2.33 D
Thermochemistry
Std molar entropy (S⦵298) 306.6 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -18.6 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -4078.8 kJ/mol
Hazards
Main hazards Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation.
GHS labelling GHS02, GHS07, GHS08
Pictograms GHS07
Signal word Warning
Hazard statements H302, H315, H319, H332
Precautionary statements P261, P264, P271, P280, P301+P312, P302+P352, P305+P351+P338, P337+P313, P501
NFPA 704 (fire diamond) 2-Phenoxyaniline: 2-2-0
Flash point 159°C
Autoignition temperature 725°C
Explosive limits Explosive limits: 0.9–7.0%
Lethal dose or concentration LD50 oral rat 590 mg/kg
LD50 (median dose) LD50 (median dose): 1990 mg/kg (oral, rat)
NIOSH SN36700
PEL (Permissible) Not established
REL (Recommended) 200 mg/L
IDLH (Immediate danger) IDLH: 25 mg/m3
Related compounds
Related compounds Aniline
Diphenyl ether
4-Phenoxyaniline