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Product Name: 2-Ethoxyethanol
Synonyms: Ethylene glycol monoethyl ether, Cellosolve, Glycol ether EE
CAS Number: 110-80-5
Recommended Use: Solvent in paints, varnishes, cleaning, inks
Manufacturer: Contact information from supplier or distributor
Emergency Phone Number: Listed on supplier's label or SDS sheet
Molecular Formula: C4H10O2
Molecular Weight: 90.12 g/mol
GHS Classification: Flammable liquid (Category 3); Acute toxicity, oral (Category 4); Acute toxicity, dermal (Category 4); Eye irritation (Category 2A); Reproductive toxicity (Category 1B)
Signal Word: Danger
Hazard Statements: Flammable liquid and vapor; Harmful if swallowed or in contact with skin; Causes serious eye irritation; May damage fertility or the unborn child
Pictograms: Flame, exclamation mark, health hazard
Precautionary Statements: Keep away from heat, sparks, open flames; Wear protective gloves, eye/face protection; Wash thoroughly after handling; Do not eat, drink or smoke when using
Chemical Identity: 2-Ethoxyethanol
Concentration: ≥99% (technical or reagent grade)
CAS Number: 110-80-5
Impurities: May include trace levels of related alcohols or ethers (each below 0.5%)
Other Components: No significant non-hazardous ingredients reported when pure
Inhalation: Move exposed individual to fresh air, keep at rest. Monitor for respiratory distress. Seek medical attention if symptoms like headache, nausea, or drowsiness develop.
Skin Contact: Immediately wash exposed skin with plenty of water for at least 15 minutes. Remove contaminated clothing. Consult physician if irritation persists.
Eye Contact: Rinse eyes cautiously with running water for several minutes, holding eyelids open. Remove contact lenses if present and easy. Continue rinsing and get medical care.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek immediate medical advice.
Most Important Symptoms: Headache, drowsiness, nausea, eye and skin irritation, damage to organs with prolonged exposure (like kidney, liver, reproductive organs)
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide (CO2). Water spray to cool containers.
Unsuitable Media: Direct water jets may spread fire.
Specific Hazards: Vapors form explosive mixtures with air; containers can explode in heat; combustion releases toxic gases (carbon monoxide, carbon dioxide).
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus.
Special Procedures: Keep people away; cool exposed containers with spray; stay upwind
Personal Precautions: Evacuate area, ventilate. Avoid breathing vapors. Use personal protective equipment (respirator, gloves, goggles). Remove ignition sources.
Environmental Precautions: Prevent entry into drains, waterways, soil.
Methods for Clean-up: Soak up spill with inert material (vermiculite, sand), collect in a closed chemical waste container. Mop or wash area thoroughly after initial pick-up.
Further Precautions: Notify authorities if large environmental release occurs.
Precautions for Safe Handling: Avoid contact with skin, eyes, clothing. Do not breathe mist, vapor. Use with adequate local exhaust. Keep container tightly closed.
Safe Storage Conditions: Store in a cool, dry, ventilated area, away from ignition sources and incompatible materials (oxidizers, acids, alkalis). Keep in properly labeled and tightly sealed containers. Protect from direct sunlight and heat sources.
Incompatible Materials: Strong oxidizing agents, acid chlorides, anhydrides, peroxides. Avoid aluminum or zinc for containers.
Special Storage: Ground and bond containers and transfer equipment to prevent static discharge.
Occupational Exposure Limits: OSHA PEL: 200 ppm TWA; ACGIH TLV: 5 ppm TWA, skin notation
Engineering Controls: Adequate general and local exhaust ventilation; closed systems where feasible
Personal Protection: Chemical-resistant gloves (nitrile, neoprene), splash-proof goggles, face shield, impervious clothing. Use NIOSH-approved respirator if exposure may exceed recommended limits.
Hygiene Measures: Wash hands and face before breaks and after work. Remove and wash contaminated clothing before reuse.
Appearance: Colorless, transparent liquid
Odor: Mild ethereal odor
Boiling Point: 135°C (275°F)
Melting Point: -70°C (-94°F)
Flash Point: 38-43°C (100-110°F) (closed cup)
Vapor Pressure: 7.8 mmHg at 25°C
Solubility: Miscible with water, alcohols, and many organic solvents
Density: 0.931 g/cm³ at 20°C
pH: Not applicable
Viscosity: 1.7 mPa·s at 20°C
Partition Coefficient (log Kow): -0.32
Chemical Stability: Stable under recommended storage conditions.
Conditions to Avoid: Elevated temperatures, open flames, sparks, static discharge.
Materials to Avoid: Strong oxidizers, mineral acids, alkali metals, acid chlorides.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, smoke, other irritating gases.
Polymerization: Will not occur under normal operational conditions.
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact.
Acute Toxicity: Oral LD50 (rat): 2,460 mg/kg; Dermal LD50 (rabbit): 3,000 mg/kg; LC50 Inhalation (rat, 4h): 1,100 ppm
Health Effects: Harmful if swallowed, inhaled, or absorbed through skin. Eye and respiratory tract irritation, systemic toxicity affecting central nervous system, blood, kidney, and liver.
Chronic Toxicity: May cause genetic defects, reproductive toxicity (risk of harm to the unborn child). Prolonged exposure can lead to anemia, liver or kidney dysfunction.
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA; evidence for reproductive health effects in animal studies.
Symptoms of Overexposure: Drowsiness, headache, nausea, dizziness, shortness of breath, abdominal pain, possible unconsciousness.
Ecotoxicity: Toxic to aquatic life at high concentrations. Fish LC50 (96 h): 1410 mg/L (Oncorhynchus mykiss). Daphnia EC50 (48 h): 2127 mg/L. Algae EC50 (72 h): 900 mg/L.
Persistence and Degradability: Readily biodegradable under aerobic conditions.
Bioaccumulative Potential: Low bioconcentration factor (BCF = 0.2)
Mobility in Soil: Expected to have very high mobility; may leach to groundwater.
Other Adverse Effects: Contamination may cause harm to aquatic invertebrates if significant spillage enters waterways.
Waste Disposal: Dispose of contents/container as hazardous waste per local, state, and federal regulations. Incinerate only in permitted facilities.
Special Precautions: Do not discharge to sewer system or uncontaminated ground; prevent release to environment.
Contaminated Packaging: Triple rinse, crush or puncture before disposal; dispose as hazardous chemical waste.
Recycling: Not recommended due to toxicity; specific arrangements required for recovery or solvent reclamation
UN Number: UN 1171
Proper Shipping Name: Ethylene glycol monoethyl ether
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labeling Requirements: Flammable liquid symbol
Special Precautions for User: Keep container upright and secure during transport
Environmental Hazards: Not regulated as marine pollutant.
US TSCA: Listed
EU REACH: Registered substance; subject to Annex XVII restrictions
OSHA Hazard Communication: Considered hazardous
SARA Title III (Sections 311/312): Immediate health, Fire hazard
SARA Title III (Section 313): Reportable chemical
California Proposition 65: Listed as reproductive toxicant
Canadian WHMIS: Class B2: Flammable liquid, D2A/B: Toxic
Other: Always refer to local, regional, and national regulations for additional restrictions or requirements on storage, use, or disposal.
