Yudu County, Ganzhou, Jiangxi, China sales3@ar-reagent.com 3170906422@qq.com
Follow us:



Reflecting on 2-Amino-5-Hydroxybenzoic Acid: Past, Present, and Possibilities

Tracing the Roots and Evolution

Science tends to cycle between rediscovery and innovation. Just look at the story of 2-Amino-5-hydroxybenzoic acid. Chemists homed in on this compound as far back as the early part of the last century, when the benzene ring stood as the building block of organic chemistry. Aromatic amino-hydroxy acids drew interest, since each functional group opened doors to different reactivity and new chemistry. Early researchers found that adding both an amino and hydroxy group had ripple effects in both biological and synthetic worlds, from dye production to efforts in drug synthesis. Later, as chromatography improved, separation and analysis of complex benzoic acid derivatives like this one became less of a hurdle. From reaction monitoring in glass tubes to high-pressure columns and NMR scans, the field moved fast. I remember my own pivot to organics, marveling at how methodical advances—some from forgotten footsteps—shaped what felt like entirely modern research.

A Closer Look at Form and Structure

2-Amino-5-hydroxybenzoic acid grabs attention not by flash, but through practical chemistry. The white to off-white crystalline powder signals purity, while its modest solubility in water anchors its use for controlled reactions rather than frivolous mixing. Its melting point, typically reported above 200°C, gives a hint of stability—a blessing for handling but a subtle challenge for certain chemical reactions. The arrangement of its functional groups, with the amino group positioned ortho to the carboxyl, brings in that unique electron distribution chemists watch for. This structure, mapped out in diagrams and sometimes models, has consequences for everything from reactivity to hydrogen bonding. The chemical formula C7H7NO3 appears simple at a glance, but each atom stands poised for interaction, whether attaching to metal ions or blending into larger synthetic schemes.

Labeling and Analytical Truths

Accurate technical descriptions matter more than most folks realize. In a field full of lookalikes, precise labeling and identity tests—infrared spectra for functional groups, HPLC retention times for quantification—make the difference between promising results and ambiguous error. Research teams rely on analytical certainty to track side products, verify synthetic routes, and avoid costly setbacks. From my own experience, poorly labeled batches grind lab progress to a halt. Certificates of analysis and standardized nomenclature give everyone a common language, cuts through confusion, and grounds new findings with confidence. It’s easy to overlook, but the painstaking work of chemical characterization underpins every breakthrough.

Peering Inside Synthesis

The preparation of 2-amino-5-hydroxybenzoic acid hasn’t changed its guiding logic: control functional group introduction on the aromatic ring. Routine methods often start from divergent routes—sometimes via nitrobenzoic acid reduction, other times through diazotization and subsequent substitution to swap nitro or amine with hydroxy at precise positions. Tinkering with solvent, temperature, and reduction conditions changes yields and purity, as old lab notebooks plainly show. Scale-up from milligrams to grams challenges anyone who assumes lab protocols transfer seamlessly to bigger reactors. Lab safety, disposal of reducing agents, and pursuit of greener alternatives have grown more prominent over the years, especially as industry and academia feel pressure to cut hazardous waste. I’ve seen teams pivot to alternative reductants or enzyme-based strategies, but even so, the backbone remains classic bench chemistry done with care and skill.

Reactivity and Modifications

This compound finds itself in the middle of synthetic crossroads. The amino and hydroxy groups show versatility. Acylation, alkylation, or simple salt formation opens a pathway to derivatives—each with its own set of reactivities and sometimes surprising biological profile changes. Sulfonation or halogenation brings even more complex products, often stepping stones in pharmaceutical or pigment development. Subtle changes in pH or choice of catalyst can tilt a reaction toward a completely new class of molecules. Having both nucleophilic and electrophilic centers on a single ring paves the way for intricate cross-coupling schemes or condensation reactions. In teaching and research environments, such flexible scaffolds offer a real-world training ground—much more so than textbook molecules that rarely leave the page. These chemical possibilities explain why researchers keep circling back to this simple but serviceable compound as a base for new analogues.

What We Call It and Why it Matters

Names matter, both for technical accuracy and for bridging across fields. Besides the systematic name 2-amino-5-hydroxybenzoic acid, chemists sometimes use synonyms such as ortho-amino-meta-hydroxybenzoic acid or its registry numbers, navigating the world of international standards with patience. In my early days, confusion over regional naming conventions stalled collaborations, especially across borders. The lesson still holds: strict attention to nomenclature ensures clarity, speeds up regulatory review, avoids duplication, and ultimately gets results out of the lab and into real-world application sooner. It’s not bureaucracy, it’s shared understanding.

Operational Safety and Risk

No one wants surprises in a chemical lab. Many benzoic acid derivatives behave well, but adding functional groups drags in new risks. 2-Amino-5-hydroxybenzoic acid carries low volatility and a modest acute hazard profile, yet dust generation or accidental mixing with strong acids or bases can produce hazardous situations. Understanding safe storage and handling protocols—ventilation, glove selection, regular training—protects both people and the environment. I’ve seen research grind to a halt after a minor incident sparked regulatory review, driving home the value of a safety culture. Following evolving standards from international bodies and integrating recent toxicity findings into MSDS documentation gives scientists and workers the information to make good decisions, even amid a stressful synthesis or deadline pressure.

Application Landscape

This compound’s place in lab and industry spotlights the adaptability of benzenoid chemistry. In pharmaceutical research, it regularly pops up as a building block in efforts to find new enzyme inhibitors and anti-inflammatory agents, taking cues from natural product structures. Analytical chemists exploit its chelation properties in studies tracking metal ions, where selective binding to the amino and hydroxy groups leads to color changes or signal shifts. Dye chemists and material scientists have explored its derivatives for colorants, resins, and even some early electronic applications. These broad interests come not only from ease of synthesis, but from the way one functional group can unlock a branch of possibilities—proving once again that practical molecules shape tangible progress.

Ongoing R&D and the Noisy World of Discovery

Each time I visit a research conference, I see new work building off core aromatics like this one. Modern labs screen libraries of derivatives against diseases unheard of a generation ago. Computational chemists predict binding affinities before synthesis begins, saving months of tiresome benchwork. The shift toward predictive, data-rich research keeps driving demand for pure intermediates and new analytical techniques. Still, the human element remains—small errors and creative guesses alike shift the direction of discovery. The robust nature of 2-amino-5-hydroxybenzoic acid means it retains value as a scaffold for medicinal chemists, a testbed for reaction optimization, and a perennial standard in teaching labs. Funding cycles and publication trends come and go, but the best ideas often return to these reliable chemical workhorses.

Toxicity and Health Research

Early investigations into this compound’s toxicity settled basic issues, showing low acute toxicity and little bioaccumulation. More recent interest focuses on chronic exposures and the behavior of related derivatives in biological systems. Advances in spectroscopy and cell modeling have pointed toward relatively low mutagenicity and good metabolic clearance, though caution still rules, especially for industrial scale-ups or animal model testing. Academic studies raise concern over potential breakdown products, highlighting gaps in understanding the effects of impurities or long-term use. Few chemicals are ever “risk-free”—regulators and company safety officers keenly watch new toxicological data. For bench scientists, straightforward procedures—good ventilation, gloves, proper disposal—set a baseline for risk management. Improvements in green chemistry have begun to trickle down, lowering both lab and environmental exposures, but the topic deserves continued vigilance as techniques and uses evolve.

Building Toward the Future

Affordable, versatile aromatic acids remain invaluable in pushing research forward. The future for 2-amino-5-hydroxybenzoic acid will likely tie into expanded library screening in drug research, smarter routes that replace hazardous solvents, and further exploration of electronic materials. With ongoing climate and health concerns, demand for greener production methods will likely rise. Automated synthesis and purification, tighter analytical controls, and a willingness to revisit “old” compounds in new contexts will keep this and related molecules essential in both lab and industry. Having watched so much incremental progress over the years, I take the view that the intersection of safety, creativity, and honesty in reporting will define the next chapter—not just for those who handle 2-amino-5-hydroxybenzoic acid, but for anyone who sees promise in the chemistry of small, sturdy molecules.




What is the main use of 2-Amino-5-Hydroxybenzoic Acid?

Digging Into the Main Use

Walking into most chemistry labs, you’ll spot trays of modest, crystalline powders. Many don’t stand out by appearance alone, but some of these compounds fuel vital research and new drug development. 2-Amino-5-hydroxybenzoic acid, sometimes called anthranilic acid’s cousin, falls right into this hardworking group. Its solid reputation comes from its use as a building block for medicines and research chemicals.

I once worked alongside researchers screening new active molecules for pain relief. In that process, this compound popped up again and again on ingredient lists. Medicinal chemists blend it into new molecules aiming for targeted results. The structure—an amino group and a hydroxy group plugged onto a benzoic acid ring—helps it slot snugly into larger frameworks. This flexibility makes it a backbone for projects creating anti-inflammatory drugs, cancer agents, and treatments for nervous system disorders.

A Go-To Ingredient for Pharmaceutical Syntheses

The pharmaceutical world keeps searching for molecules that can do more with less risk. 2-Amino-5-hydroxybenzoic acid makes serious progress possible. When chemists try to create different versions of “lead” compounds, they tap into this acid’s structure to give their new molecules unique physical and chemical features. Tweaking the positions of amino or hydroxy groups lets scientists fine-tune their candidates for better potency or fewer side effects.

Take the case of nonsteroidal anti-inflammatory drugs (NSAIDs). Many common pain relievers share an evolutionary link with benzoic acid. Chemists studying new, safer anti-inflammatories often explore compounds built with pieces like 2-amino-5-hydroxybenzoic acid. It offers stable chemistry and reliable reactions—not to mention its starting materials are readily available, so labs don’t run into many sourcing headaches.

Beyond Drugs: Dyes and Analytical Work

Pharmaceutical applications get most of the headlines, but this compound also plays a smaller part in dye chemistry. Synthetic dyes depend on intricate patterns of electrons, and the unique positioning of the amine and hydroxy groups makes everything from fabric stains to lab indicators work better. I’ve seen it pop up in analytical chemistry too—helping test for trace metals, serving as a base for color changes, even making complex reactions stand out for easier tracking.

Challenges and Smart Solutions

Any molecule that draws this much interest eventually stirs up questions about safety and the environment. The pull between innovation and responsibility shows up in the laboratory every day. Chemists are working to clean up old methods—looking for solvent-free processes, greener chemistry approaches, and ways to recover reagents without wasting resources. Some teams have invested in flow chemistry setups, which use small-scale continuous reactions to make production safer, cleaner, and more efficient. Back when I worked in a lab with limited waste disposal, these efforts meant fewer headaches for everyone.

Sometimes, older chemicals pose storage concerns or give rise to byproducts worth a second look. So, tighter quality checks now keep both manufacturing and downstream users safer. Regulatory groups push for more transparent tracking of all chemicals in the supply chain. In day-to-day practice, scientists pay close attention to storage stability and proper waste management. Good science and common sense share equal billing.

Why It Matters

Creating new medicines or industrial solutions doesn’t happen in a vacuum. 2-Amino-5-hydroxybenzoic acid stands out as a quiet foundation for discovery, especially in the hunt for therapies that touch millions of lives. It matters because it lets scientists move fast, stay flexible, and push for safer and smarter tools for future generations.

What is the chemical formula and molecular weight of 2-Amino-5-Hydroxybenzoic Acid?

The Formula: Simplicity Behind the Science

2-Amino-5-hydroxybenzoic acid carries the chemical formula C7H7NO3. This structure reflects a benzene ring with three key substitutions: a carboxylic acid group, a hydroxyl group, and an amino group. It aligns closely with the well-known structure of salicylic acid but stands out due to the presence of the amino group.

Looking at the Molecular Weight

This molecule weighs in at 153.14 grams per mole. Knowing the precise mass helps in the preparation of laboratory reagents and anything from calibration standards to applications in pharmaceutical chemistry. A small shift in structure, like swapping a hydrogen for an amino group, can push the mass in a direction that supports unique chemical behaviors.

Hands-On Experience: Lab Prep Realities

Anyone who’s worked in a teaching lab knows the setting well—row after row of clean glassware, bottles stenciled with long chemical names. Accuracy carries real meaning during reagent preparation. If you weigh out chemicals and get the molecular weight wrong, nothing aligns. Solutions turn out too weak or too strong. A difference of just a single atom in the formula leads to real consequences. Mistakes with structures like C7H7NO3 can throw months of work off track.

The Role of This Compound

2-Amino-5-hydroxybenzoic acid appears in a few specialized applications. Organic synthesis is where I’ve seen it most often. Medicinal chemists tweak aromatic rings in search of new drugs, and molecules like this offer a flexible platform. You’ll find its relatives among drugs, dyes, and even materials research. The hydroxyl and amino groups work like handles—able to connect to other building blocks or steer reactivity in complex pathways.

Why Facts Matter in the Lab and Beyond

Recall a project working with student researchers, trying to make a novel compound by modifying benzoic acids. We ran into a snag because the lab manual had a typo in the chemical formula. Hours spent cross-checking, matching melting points, and recalculating doses. It was a reminder that simple data—like formula and molecular weight—carries a lot of weight. E-E-A-T principles don’t just serve digital content; in chemistry, accuracy and trust underpin every safe and successful experiment.

Improving Chemical Education and Data Access

Instead of burying formula and mass in dense tables, clear presentation up front helps students and researchers avoid error. Interactive software and open databases pave the way for anyone to double-check details like C7H7NO3 in seconds. More transparency in data sharing would keep professionals and students on the same page, cut down on wasted effort, and reduce lab accidents.

Responsible Use and Safety

Chemicals with amines and phenols tend to need more attention for safe handling. Gloves, eyewash stations, and fume hoods play their part. The molecular details feed directly into how safety protocols get designed. Being able to quickly pull up information like formula and weight never feels like trivia—it’s a real foundation for safer and more productive research.

Is 2-Amino-5-Hydroxybenzoic Acid soluble in water or organic solvents?

The Chemistry Behind Solubility Decisions

2-Amino-5-hydroxybenzoic acid, sometimes called anthranilic acid’s hydroxy cousin, offers some headaches for anyone trying to dissolve it. Its structure packs both an amino group and a hydroxyl group onto a benzoic acid ring. That mix of polar groups mixed with a bulky aromatic core creates an interesting tug of war: a molecule trying to play both sides, water and organic solvents, but never happy with just one.

Real-World Lab Experiences

Back in my undergraduate days, the hardest part of making a good buffer was keeping specialty amino acids suspended. I remember trying to dissolve 2-amino-5-hydroxybenzoic acid in basic water using a little heat and thinking it would vanish right away. Truth hit fast: you can get it to dissolve, but only with compromise. A little base nudges the acid group to its more soluble salt form, and suddenly you see a cloudy solution clear up. Try to keep it neutral or acidic, and residue collects at the bottom—sometimes clings to the beaker like a stubborn paste.

This isn’t some strange fluke. Solubility depends heavily on pH. In water, 2-amino-5-hydroxybenzoic acid barely dissolves at room temperature—a few milligrams per milliliter at best without pH manipulation. Charge matters in a big way. Add sodium hydroxide or potassium carbonate, and you get the conjugate base, boosting solubility by orders of magnitude. But most biologists, chemists, and students don’t want to keep track of the pH swings for every solution.

Organic Solvents: Old Tricks, New Problems

These polar functional groups love making hydrogen bonds, which usually means decent water compatibility. But the aromatic backbone tries to pull things the other way, making hydrophobic solvents like chloroform, toluene, or hexane useless. In DMSO or DMF, the acid and amine both find themselves at home. These high-boiling solvents take anything with a little polarity and give it room to breathe. Ethanol and methanol perform decently, but reaching high concentrations is a losing battle.

Why Solubility Matters—From Synthesis to Health

Some pharmaceuticals draw inspiration from compounds like 2-amino-5-hydroxybenzoic acid. Solubility limits influence everything, starting with synthesis itself. If the precursor barely dissolves, even high-yield reactions slow to a crawl. Waste rises, purity dips, and every wash and recrystallization turns into a guessing game. Students and seasoned chemists alike end up pouring precious time, money, and solvent down the drain.

Low water solubility also spells trouble for drug development. The body is mostly water, so anything meant to travel through blood needs to get along with aqueous surroundings. If a molecule refuses to dissolve, it never even gets the chance to show off any pharmacological power.

Supporting the Facts—Data and Published Studies

Lab data points echo across organic chemistry textbooks and databases. The Merck Index and Sigma-Aldrich literature both keep notes on this molecule’s struggle with water. Researchers measured its solubility as under 0.1 g per 100 ml at room temperature in neutral water. Shift the environment to a pH above 9, or use DMSO, and the difference becomes obvious almost instantly. Peer-reviewed studies from the Journal of Chemical & Engineering Data back up these numbers with direct measurement, showing the jump once deprotonated.

Finding Solutions in Everyday Practice

Practical chemists and students keep a mental toolbox ready. Adjust pH first, aiming for the basic side without overshooting into decomposition. For stubborn cases, try dissolving in DMSO or a mix of water and ethanol. If the project has a pharmaceutical angle, turn to salt formation—transform the acid into its more soluble sodium or potassium derivative. Academic journals and forums like the StackExchange chemistry board collect plenty of field-tested tips for anyone in need of a quick fix.

Forget fantasies about dissolving this compound in plain water or every organic solvent on the shelf. Hands-on experience and years of published data point in the same direction: without pH shifts, strong polar organic solvents, or good salt prep, you’re left with a gritty, half-dissolved mess and hours lost to trial and error.

What are the storage and handling recommendations for 2-Amino-5-Hydroxybenzoic Acid?

Understanding the Material

2-Amino-5-hydroxybenzoic acid, also known as anthranilic acid derivative, plays a crucial role in many organic synthesis labs and research facilities. Anyone handling fine chemicals can tell you that keeping materials stable saves money, time, and keeps people safe. I’ve worked in labs that struggled with product loss or safety risks just from missing clear storage basics. Such headaches multiply with aromatic amines like this one—both because of their chemical reactivity and their health risks.

Essential Storage Approaches

This compound thrives best in a sealed environment. Exposure to open air or moisture degrades purity over time. Moisture doesn’t just cause clumping; it also raises the chance of breakdown or unexpected reactions. Storing 2-amino-5-hydroxybenzoic acid in an airtight glass bottle, tucked away from high humidity, keeps its integrity intact.

Direct sunlight and high temperatures eat away at the usefulness of most aromatic acids. Keeping stock bottles off benches or window ledges goes a long way. A dark, dedicated cabinet—ideally temperature-controlled between 15°C and 25°C—offers an ideal haven for this material.

Material Handling Practices

Most labs keep simple rules in place for chemicals that carry both health hazards and reactivity. 2-amino-5-hydroxybenzoic acid may irritate skin, eyes, and the respiratory system. Wearing gloves, using goggles, and working in a fume hood become routine for good reason—once, in a rush, I skipped these and ended up with irritated hands from a minor spill. Lessons stick fast that way.

Transfer powder using a clean spatula, not by pouring or shaking. Static or splatter can waste product or raise dust. Respirators often feel like overkill, but for larger quantities or regular work, they make a noticeable difference. Any spill, even a small one, should get cleaned right up using damp paper towels, then dropped in the hazardous waste.

Labeling and Inventory

Proper labeling is a legal requirement, but more than that, it becomes a daily tool for preventing confusion, especially during audits or emergencies. Clear labels with chemical name, date received, expiration, and hazard pictograms stop accidental misuse. Every so often, I’ve seen labs ignore dates, only to discover degraded material during crucial research. Rotating stock and logging every withdrawal avoids this pitfall.

Safe Disposal

Leftover acid or contaminated material should never run to the sink. Collection drums or secondary containment keep waste out of the environment. Local regulations dictate final disposal, but the main idea is simple: treat chemical waste with respect. Working in a lab that once poured organics down the drain showed me how fast poor habits can lead to environmental trouble and fines.

Investing in Training

No handbook beats hands-on mentoring. Regular staff training, including refreshers, builds habits that stick. Bringing new techs into the fold means showing—not just telling—the best ways to store and handle 2-amino-5-hydroxybenzoic acid. Questions and mistakes surface early, and everyone works safer in the long run.

Supporting Reliable Research

Paying attention to these basics helps research stay on track and keeps labs safe. With the right storage and handling, this material supports breakthroughs, instead of causing setbacks in the lab or safety office. Every step taken up front repays itself many times over in peace of mind and research results you can trust.

Are there any known hazards or safety precautions for using 2-Amino-5-Hydroxybenzoic Acid?

What Really Matters About Chemical Handling

I’ve worked around chemicals for years, and if there’s one lesson that stuck, it’s this: even with “mild” compounds, you never get casual. 2-Amino-5-Hydroxybenzoic Acid shows up in specialized labs and chemical research. Folks sometimes think lesser-known chemicals don’t pose real risks. Truth is, even compounds that sound obscure can create headaches—or something worse—if you skip good habits.

The Facts: Exposure Risks

For 2-Amino-5-Hydroxybenzoic Acid, main exposure routes come through skin or eyes, sometimes by breathing in dust if the powder form floats around during weighing or mixing. Handling this acid with bare hands isn’t smart. Skin irritation can flare fast, especially for anyone with sensitive skin or existing allergies. If it gets in the eyes, stinging and redness follow right after. I’ve seen coworkers rush to the eyewash in pain; trust me, it’s no joke.

No strong evidence exists showing this compound leads straight to cancer or causes long-term organ damage. Still, suppliers usually call for caution, and the safety data sheet pushes for gear like gloves, goggles, and dust masks if there’s any danger of particles escaping. Respiratory problems show up when people shrug off dust control, which leads to cough, soreness, and sometimes trouble breathing.

How to Minimize Hazards

Workers sometimes ask if just wearing disposable gloves works. Nitrile gloves do the job unless the glove rips or someone wipes their face. It’s smart to double up with eye protection, because regular glasses don’t count as a safety barrier. I always reach for the face shield with anything new—hard to regret that. As for ventilation, a simple fume hood makes handling powders much safer, especially since accidental spills shoot dust everywhere in a flash.

Chemicals find sneaky ways of lingering on benches and equipment. Routine cleaning—wiping surfaces with damp cloths and using mild detergent—keeps residue down. I learned the value of good cleaning after seeing test results skewed by cross-contamination. Marking containers with clear labels avoids confusion too, since unlabeled powder left in the open leads to mix-ups and wasted hours double-checking samples.

Accidents and What to Do

The best plan covers accidents before they happen. After a spill, the steps stay simple: scoop powder gently with a spatula, never brush or blow it, and stick it straight into a safe waste container. Water handles most acid residues well for cleanup, but never rush straight in. I once saw a new technician turn a dry spill into sticky goo just by pouring water—making the mess tougher to clean. Small, repeated wipes with minimal dampness work better.

If someone accidentally touches or swallows the chemical, don’t play it down. Immediate rinsing with water, removing contaminated clothing, and getting professional help beat any delay. Rapid response lowers the odds of bigger trouble, like an allergic reaction.

Building Better Safety Habits

Getting sloppy with safety rarely bites back the first day, but habits slip over time. Training never wastes anyone’s energy. I update myself on safety data sheets any time a new supply arrives, since even minor tweaks in purity can change recommended gear. Labs with a clear set of written protocols handle emergencies with less chaos. Posting key contacts near phones helps keep panic in check if an incident breaks routine.

Looking for Solutions

People often overlook substitution. If a research step allows switching to a compound with fewer risks, that cuts hazards at the source. For cases where substitutions don’t fly, building in steps like regular safety checks, updated emergency drills, and easy access to protective gear makes a lab’s safety culture stronger every day. Listening to workers about real-world inconveniences leads to easier buy-in for safety measures. At the end of the day, staying alert and respecting even “simple” chemicals keeps teams out of trouble and projects on schedule.

2 - Amino - 5 - Hydroxybenzoic Acid
Names
Preferred IUPAC name 2-amino-5-hydroxybenzoic acid
Other names Anthranilic acid, 5-hydroxy-
2-Amino-5-hydroxybenzoic acid
Sulfanilic acid
5-Hydroxyanthranilic acid
Pronunciation /tuː əˈmiːnoʊ faɪv haɪˈdrɒksɪbɛnˈzoʊɪk ˈæsɪd/
Identifiers
CAS Number 89-52-1
3D model (JSmol) `3D model (JSmol)` string for **2-Amino-5-hydroxybenzoic acid**: ``` c1cc(c(cc1O)N)C(=O)O ``` This is the **SMILES** string representing the molecule, which can be directly used in JSmol for 3D visualization.
Beilstein Reference 157648
ChEBI CHEBI:27759
ChEMBL CHEMBL244052
ChemSpider 57583
DrugBank DB08498
ECHA InfoCard ECHA InfoCard: 100.006.160
EC Number 210-396-0
Gmelin Reference 114228
KEGG C06509
MeSH D08.811.277.040.400.700.150.235
PubChem CID 85524
RTECS number VL7030000
UNII P6K7T5B59N
UN number UN2811
CompTox Dashboard (EPA) DTXSID7040823
Properties
Chemical formula C7H7NO3
Molar mass 153.14 g/mol
Appearance Light brown to beige powder
Odor Odorless
Density 1.485 g/cm³
Solubility in water Soluble
log P 0.24
Vapor pressure 2.57E-6 mmHg at 25°C
Acidity (pKa) 2.69
Basicity (pKb) 7.68
Magnetic susceptibility (χ) -23.0 x 10^-6 cm³/mol
Refractive index (nD) 1.672
Dipole moment 3.25 D
Thermochemistry
Std molar entropy (S⦵298) 163.6 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -320.3 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -1292 kJ·mol⁻¹
Pharmacology
ATC code N02BA11
Hazards
Main hazards Irritating to eyes, respiratory system and skin.
GHS labelling GHS02, GHS07
Pictograms GHS07
Signal word Warning
Hazard statements H302, H315, H319, H335
Precautionary statements Precautionary statements: P261, P305+P351+P338, P337+P313
NFPA 704 (fire diamond) 1-2-0
Flash point > 259.5 °C
Autoignition temperature > 585 °C
Lethal dose or concentration LD50 oral rat 373 mg/kg
LD50 (median dose) LD50 (median dose): Mouse oral 400 mg/kg
NIOSH ZE2625000
PEL (Permissible) PEL (Permissible) for 2-Amino-5-Hydroxybenzoic Acid: Not established
REL (Recommended) 0.1 mg/m³
IDLH (Immediate danger) No IDLH established.
Related compounds
Related compounds Salicylic acid
Anthranilic acid
2,5-Dihydroxybenzoic acid
p-Aminobenzoic acid
m-Aminophenol