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Name: 2,2-Diphenylglycine
Chemical Formula: C14H13NO2
Common Uses: Intermediate in organic synthesis, building block in pharmaceuticals, sometimes appears in research labs focused on amino acid derivatives.
Appearance: Solid, usually in white crystalline powder form.
Odor: Nearly odorless.
Synonyms: Benzhydrylglycine.
CAS Number: 3549-28-8
Potential Presence: Universities, specialty chemical manufacturers, research institutes.
Status: Not classified under many global standards as highly hazardous, but chemical manipulation still brings risk.
Main Hazards: Prolonged skin or eye contact may cause irritation; ingestion brings risk of gastrointestinal distress.
Environmental Impact: Potential for aquatic impact if released in significant quantities.
Physical Hazards: Combustible dust can appear with fine powders, especially in poorly ventilated spaces.
Chronic Exposure: Data is sparse, but standard safety practices suggest treating repeat or high-dose exposure with caution.
Main Component: 2,2-Diphenylglycine
Typical Purity: Often above 95% for laboratory and industrial uses.
Impurities: Trace amounts of related aromatic compounds, unreacted precursors.
Additives: Generally absent unless supplied as blended for specific research purposes.
Inhalation: Move to fresh air; respiratory discomfort may appear if dust levels are high, so up-to-date local exhaust ventilation helps.
Skin Contact: Rinse with water and remove anything contaminated; persistent irritation should prompt medical evaluation.
Eye Contact: Flush with running water for several minutes, keeping eyelids apart.
Ingestion: Do not induce vomiting, rinse mouth with water, seek medical input if symptoms arise.
General Input: Familiarity with emergency showers and eyewash stations is useful for all working in chemical research or synthesis labs.
Suitable Extinguishers: Use standard water spray, carbon dioxide, or dry chemical extinguishers; these are the backbone of most lab setups.
Fire Hazards: Decomposition during burning can release noxious fumes including carbon oxides and nitrogen oxides, so self-contained breathing apparatus makes sense for responders.
Protective Equipment: Firefighters rely on full gear including gloves, boots, and face shields.
Tactical Considerations: Clearing the area and containing run-off can help limit environmental impact if a larger cache is involved.
Personal Precautions: Immediate step back for spills, avoid direct contact, wear gloves and goggles.
Methods for Clean-Up: Scoop solid material, sweep up gently to minimize dust, and use damp cloths for residue; avoid dry brushing large amounts.
Ventilation: Open windows and use fans if available.
Environmental Protection: Prevent entry to drains; spills should get collected in closed containers for disposal according to local regulations.
Handling Practices: Always wear protective gloves and use goggles, never eat or drink around chemical stocks.
Workplace Hygiene: Wash hands thoroughly after handling.
Storage Conditions: Keep containers tightly shut, store in a cool, dry spot away from strong acids or oxidizers.
Shelving Requirements: Use chemical-resistant shelving; avoid wooden materials in case of spills.
Segregation: Separate from incompatible materials to prevent unwanted reactions or contamination.
Engineering Controls: Fume hoods minimize dust exposure, and local exhaust ventilation keeps air quality above par.
PPE for Routine Use: Safety goggles, lab coat, and nitrile or rubber gloves.
Respiratory Protection: If dust becomes significant, use particulate masks.
Environmental Monitoring: Regular air quality checks in labs keep potential exposure low.
Housekeeping: Spill kits and regular cleaning routines help deter accidental contact.
Physical State: Solid
Color: White to off-white powder.
Melting Point: Ranges from 180 to 185°C.
Solubility: Slightly soluble in water, more soluble in organic solvents like ethanol.
Odor Threshold: No noticeable odor at routine concentrations.
Vapor Pressure: Negligible at room temperature.
Boiling Point: Data limited, often not achieved before decomposition.
Chemical Stability: Stable under standard conditions when sealed and kept dry.
Reactivity Concerns: Reacts with strong acids, bases, and oxidizing agents.
Hazardous Decomposition: Heating to decomposition brings releases of carbon monoxide, carbon dioxide, and nitrogen oxides.
Avoidance: Keep away from open flames, sources of ignition, or incompatible mixtures during operations.
Polymerization: No known tendency to undergo uncontrolled polymerization.
Acute Effects: Dust inhalation or direct skin contact causes irritation; ingestion brings discomfort but usually not life-threatening at lab scale.
Chronic Effects: Not enough evidence to outline chronic toxicity from low-dose exposures.
Sensitization: Rare, but individuals with sensitive skin may develop mild reactions.
Mutagenicity and Carcinogenicity: No evidence supporting mutagenic or carcinogenic effects based on available data.
Observational Gaps: Few large-scale human studies, so prudent handling reflects a science-based respect for unknowns.
Aquatic Toxicity: Lacking comprehensive studies, safe practice suggests keeping out of rivers, streams, and groundwater.
Persistence: Organic compounds tend to linger in soil if improper disposal occurs.
Bioaccumulation: No clear data to suggest significant risk, but routine waste removal reduces concerns.
Biodiversity Impact: Accidental releases should still get contained to avoid harm to aquatic life and beneficial soil microorganisms.
Preferred Disposal: Hand off solid residue and contaminated materials to certified hazardous waste processors.
Waste Law: Local and national regulations govern chemical waste removal, and noncompliance can pose legal risks as well as environmental ones.
Lab Practice: Do not flush down the sink or throw with normal trash; marked chemical waste bins belong near lab benches.
Container Management: Rinse empty chemical bottles with suitable solvent, then process them by hazardous waste guidelines.
Mode of Transport: Small-scale transfers by ground typically pose less risk, but larger shipments require labeled, sealed containers.
Packing Guidelines: Well-cushioned, shatterproof packaging protects both the chemical and handlers.
Shipping Restrictions: Follows chemical transport regulation worldwide, usually not flagged as high-urgency but still demands clear labeling.
Spill Preparedness: Carriers need basic spill kits and instructions, especially for longer routes across regions without ready emergency support.
Chemical Inventory Status: Registered or permitted in most industrial and research jurisdictions.
Worker Safety Regulation: Occupational exposure controls and chemical hygiene plans in regulated workplaces provide protection.
Consumer Use: Not available for unsupervised or direct consumer handling, reflecting underlying safety policies.
Transport Coding: Falls under chemical substances with no special handling beyond what’s required for routine chemical goods.
Disclosure: Employers or supervisors bear responsibility for communicating risk and safe procedures to staff, and providing up-to-date training.
