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Chemical Name: (1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl Carbonate
Simplified Molecular Formula: C11H14O3
Description: White to off-white solid used in research and development of pharmaceuticals and advanced materials.
Scent: Faint or no detectable odor.
Uses: Synthons in organic chemistry, pharmaceutical intermediate.
Common Forms: Typically handled as a powder or crystalline solid.
Health Hazards: Inhalation, ingestion, or skin contact could irritate mucous membranes or skin. Sensitization reactions occur in individuals through prolonged handling. No confirmed carcinogenicity or teratogenicity based on available research, but limited data on human exposure.
Fire Hazards: Combustible under certain fire conditions, releasing hazardous fumes such as carbon monoxide and carbon dioxide.
Environmental Hazards: No evidence for high environmental persistence or aquatic toxicity, but precaution dictates avoiding contamination of soil and water courses.
GHS Classification: Eye irritant, skin sensitizer suspected based on chemical family characteristics.
Main Component: (1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl Carbonate
Purity Level: Often exceeds 97% in laboratory settings.
Known Additives: None specifically reported for standard samples, though trace residual solvents may remain from synthesis.
After Inhalation: Move affected person to fresh air; seek medical attention for any breathing difficulty.
Skin Contact: Remove contaminated clothing and rinse affected area with water and soap for several minutes.
Eye Contact: Rinse with clean water for multiple minutes, lifting eyelids occasionally; pursue medical advice if irritation persists.
If Ingested: Rinse mouth with water; get medical help promptly; avoid inducing vomiting unless directed by a physician.
Suitable Extinguishing Media: Dry chemical, foam, or carbon dioxide foam extinguishers reduce the spread of flame well.
Unsuitable Media: Direct streams of water often spread the powder.
Hazardous Combustion Products: Burning releases irritating or toxic vapors, notably carbon oxides.
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus help prevent inhalation injuries.
Personal Precautions: Limit skin and eye contact with chemical-resistant gloves and goggles.
Containment: Prevent compound from entering drains and sewers.
Cleanup Methods: Wet sweeping or HEPA vacuuming contains the powder for proper disposal; avoid creating airborne dust.
Disposal: Place waste in sealed containers and arrange for removal by a licensed chemical disposal contractor.
Safe Handling: Only open in a well-ventilated laboratory; always wear protective gloves, glasses, and clothing.
Avoided Conditions: Storing near strong oxidizers, acids, or heat sources increases risk.
Storage Requirements: Keep chemical in tightly sealed container in a cool, dry place away from direct sunlight and moisture.
Spill Prevention: Store chemical on spill trays or secondary containment shelves.
Engineering Controls: Work inside fume hoods whenever possible; maintain effective local exhaust.
Personal Protective Equipment: Laboratory nitrile gloves, safety goggles, and impermeable lab coats recommended.
Hygiene Measures: No eating, drinking, or smoking in work areas; wash hands and exposed skin thoroughly after handling.
Respiratory Protection: Use NIOSH-certified respirators where dust or fumes may become airborne in large concentrations.
Physical State: White to off-white crystalline powder.
Odor: Subtle or odorless.
Solubility: Partially soluble in common organic solvents, low solubility in water.
Melting Point: Range subject to purity but generally above room temperature.
Boiling Point: Decomposes before reaching boiling under atmospheric pressure; avoid heating.
Vapor Pressure: Not volatile at room temperature.
Density: Specific values depend on crystalline form but falls within the standard range for similar organics.
Chemical Stability: Remains stable under typical laboratory handling and storage conditions if moisture and oxidizers are absent.
Hazardous Reactions: Direct contact with acids or strong bases potentially leads to decomposition and release of carbon oxides.
Incompatibilities: Avoid reactions with strong oxidizing agents, strong acids and reducing agents.
Decomposition Products: Carbon dioxide, carbon monoxide, and unidentified organic fragments form under heat or fire.
Routes of Exposure: Most likely via skin, inhalation of dust, or ingestion from hand-to-mouth actions.
Acute Symptoms: Skin or eye irritation; respiratory tract discomfort through dust exposure.
Chronic Effects: No evidence for chronic toxicity after repeated small-scale laboratory handling, but lack of long-term animal studies or epidemiological data limits definitive safety claims.
Sensitization: Potential for allergic skin responses in sensitive individuals present.
Carcinogenicity/Mutagenicity: No reports indicating carcinogenic or DNA-damaging effects under standard laboratory use.
Biodegradability: No verified data on complete breakdown in natural waters or soils, though similar compounds often degrade slowly.
Aquatic Toxicity: No measured aquatic toxicity, yet all laboratory chemicals should be prevented from entering water courses.
Bioaccumulation: Structure suggests unlikely for the compound to bioaccumulate in the food chain in significant amounts.
Precautions: Responsible researchers restrict release to the environment, following stewardship principles promoted across academic and industrial laboratories.
Disposal Methods: Collect and store chemical waste in compatible, labeled containers; transfer only to licensed chemical waste contractors for incineration or chemical treatment.
Regulatory Compliance: Adherence to regional and local regulations governing hazardous organic compound disposal, often guided by EPA, EU REACH, or similar bodies' protocols.
Containment: Keep residues separated from household streams and non-hazardous wastes to avoid accidental exposure or environmental release.
Ground Shipment: Securely sealed in robust, shatter-resistant containers with clear chemical hazard labeling.
Air or Sea Freight: Packaged following IATA or IMO guidelines for laboratory chemicals if applicable; no widespread commercial shipping for this substance.
Handling Precautions During Transport: Avoid exposure to extreme temperatures or rough handling that could lead to spills.
Global Regulatory Status: Compound rarely appears on controlled substance lists; handled primarily under general laboratory chemical safety rules.
Occupational Exposure: No specific permissible exposure limits set, but rational lab practice dictates minimizing exposure regardless.
Worker Protections: Stronger emphasis on risk communication, training, and availability of MSDS details in the research sector, not just for legal compliance but for genuine workforce safety.
Research and Development: Ongoing improvements to toxicological and environmental fate data would further inform best handling and use policies in the future.
