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Product Name: 1-Trimethylsilyl Imidazole
Chemical Formula: C6H12N2Si
CAS Number: 18156-74-6
Synonyms: N-Trimethylsilylimidazole, TMS Imidazole
Recommended Use: Analytical reagent, derivatizing agent for gas chromatography
Supplier: Manufacturer’s address, emergency phone, and email to be included on the container label
UN Number: Not regulated
GHS Classification: Flammable liquid (Category 3); Skin irritant (Category 2); Eye irritant (Category 2A); Specific target organ toxicity—Single exposure (Category 3)
GHS Label Elements: Pictograms for flammable liquid, irritant
Hazard Statements: Flammable liquid and vapor; Causes skin irritation; Causes serious eye irritation; May cause respiratory irritation
Precautionary Statements: Keep away from heat/sparks/open flames. Avoid breathing fumes. Wear protective gloves, protective goggles, and face protection.
Emergency Overview: Clear liquid with pungent odor, presents an inhalation and contact hazard. Severe tissue irritant.
Chemical Identity: 1-Trimethylsilyl Imidazole
Concentration: >99% by weight
CAS Number: 18156-74-6
Impurities: Trace amounts of unreacted imidazole, trimethylchlorosilane (<0.5%)
Molecular Weight: 140.26 g/mol
Inhalation: Move person to fresh air. Seek immediate medical attention if symptoms like coughing, headache, or shortness of breath develop.
Skin Contact: Remove contaminated clothing and wash skin with copious water and mild soap for at least 15 minutes. Contact physician at once for redness, burns, or blistering.
Eye Contact: Immediately flush eyes thoroughly with clean water for at least 15 minutes, lifting eyelids. Seek urgent medical help even for minor symptoms.
Ingestion: Rinse mouth with water. Do not induce vomiting. Call Poison Center or doctor without delay.
Notes to Physician: Treat symptomatically, monitor for respiratory distress, chemical pneumonitis, or edema. Decontaminate skin and eyes promptly.
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, or alcohol-resistant foam for small fires. Water spray for larger fires by trained responders.
Hazards from Combustion: Emits toxic fumes of nitrogen oxides, silicon oxides, carbon monoxide, and carbon dioxide.
Protective Equipment: Full chemical suit and self-contained breathing apparatus for firefighters.
Special Precautions: Vapors may travel to source of ignition and flash back. Avoid using water jets.
Explosion Data: Vapor forms explosive mixtures with air. Sparking tools and open flames must be avoided in the area.
Personal Precautions: Evacuate area. Ventilate space. Avoid breathing vapors. Use protective gloves, goggles, face shield, long sleeves.
Environmental Precautions: Prevent entry into drains, surface water or soil. Inform local authorities if significant spillage occurs.
Methods for Clean-Up: Absorb spill with inert, non-combustible material like sand or earth, transfer to sealed chemical waste container. Flush surface with water after removal. Decontaminate with dilute acetic acid if appropriate.
Special instructions: Avoid sources of ignition. Use non-sparking tools. Dispose of all contaminated materials in compliance with regulations.
Safety Precautions: Store and use in well-ventilated areas. Keep container tightly closed. Avoid inhalation, contact with skin and eyes. Do not eat, drink or smoke during use.
Storage Conditions: Store in cool, dry, fireproof place, away from incompatible materials like acids, oxidizers, and moisture.
Container Requirements: Use original, labeled chemical-resistant containers.
Incompatibilities: Reacts strongly with water, acids, oxidizers, and bases, evolving heat, gases, or corrosive byproducts.
Specific Practices: Ground/bond containers when dispensing. Limit quantities in storage to reduce fire/explosion risk.
Exposure Limits: No established occupational exposure limits. Good laboratory practice calls for minimizing exposure.
Engineering Controls: Local exhaust ventilation, chemical fume hood, eye-wash and safety shower accessible.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, face shield, flame-resistant lab coat, chemical-resistant apron and closed footwear.
Respiratory Protection: Use approved organic vapor respirator if ventilation is inadequate or exposure limit risk exists.
Hygiene measures: Do not handle without proper personal protection. Wash hands and forearms after use, before eating, drinking, or restroom use.
Appearance: Clear, colorless to pale yellow liquid
Odor: Sharp, amine-like odor
Odor Threshold: Not established
pH: Not assigned, reacts with water
Melting Point: Approx. -30°C
Boiling Point: Approx. 195-198°C (at 760 mm Hg)
Flash Point: 52°C (closed cup)
Evaporation Rate: Not established
Flammability: Flammable
Explosive Limits: Not determined
Vapor Pressure: Approx. 1 mmHg (at 25°C)
Vapor Density: >1 (air=1)
Relative Density: 0.98 (water=1)
Solubility in Water: Decomposes
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: >200°C
Decomposition Temperature: No data
Viscosity: Low, characteristic of organic solvents
Chemical Stability: Stable under normal dry, cold storage conditions. Unstable with water, acids, and oxidizers, decomposing rapidly.
Potentially Hazardous Reactions: Violent hydrolysis with water or acids, releases imidazole and trimethylsilanol. Release of flammable vapors.
Conditions to Avoid: Heating, moisture, open flames, spark sources, direct sunlight.
Incompatible Materials: Water, acids, oxidizing agents. Generates pressure in sealed containers with air or acid contact.
Hazardous Decomposition Products: Nitrogen oxides, silicon oxides, carbon monoxide, trimethylsilanol
Routes of Exposure: Inhalation, skin, and eye contact, ingestion.
Acute Effects: Burns eyes, skin and mucous membranes; may cause allergic reactions or respiratory symptoms.
Chronic Effects: Prolonged or repeated exposure increases risk of dermatitis, chemical burns, or respiratory irritation.
Toxicity Data: No comprehensive specific LD50/LC50 values available. Imidazole derivatives show moderate acute toxicity.
Sensitization: Data suggests low risk for sensitization, but caution required. Not classified as carcinogen or mutagen.
Health Hazards: Can damage mucous membranes and respiratory tract if inhaled in quantity.
Symptoms: Burning pain, redness, swelling, coughing, headache, drowsiness.
Aquatic Toxicity: Limited data. Imidazole rings can pose risk for aquatic organisms at high concentrations.
Persistence and Degradation: Decomposes in water, products less persistent, but initial substance hazardous to aquatic life.
Bioaccumulation: Not readily bioaccumulative. Volatile organic fraction can move to atmosphere from water or soil.
Mobility in Soil: Reacts and decomposes, migration potential low.
Other Hazards: Prevent environmental release; follow best practices for chemical waste.
Disposal Methods: Treat as hazardous organic chemical waste. Collect in tightly sealed appropriate container for disposal by licensed professional waste handler.
Special Precautions: Flush residues with large amounts of water after neutralization. Decontaminate glassware and surfaces using standard laboratory cleaning agents with acid quench.
Regulatory Requirements: Do not dispose of via sewers or regular trash. Comply with local, state, national, and international regulations.
Empty Containers: Triple rinse, remove label, and treat as hazardous. Never reuse container for food or potable liquids.
UN Number: Not regulated as dangerous cargo for transport by land, sea, or air under most jurisdictions. Local regulations may differ.
Proper Shipping Name: 1-Trimethylsilylimidazole or laboratory chemical.
Hazard Class: Possible class 3 (Flammable liquid), but most carriers do not regulate small-lab quantities. Ship in marked, sealed containers.
Packing Group: III (for similar materials)
Label Requirements: Flammable liquid, toxic, avoid handling under moist or reactive conditions.
Reportable Quantities: Not specifically listed. Large spills require notification of local authorities.
OSHA Status: Hazardous chemical under OSHA’s Hazard Communication Standard.
TSCA Inventory: Listed
EPCRA/SARA Title III: Not subject to reporting. Not listed as Extremely Hazardous Substance.
California Proposition 65: Not listed.
Other Regulations: Compliance required with local and international chemical safety rules and workplace exposure standards. Consult MSDS regularly for updated guidance.
Label Elements: Container must display hazard pictograms and warning statements.
