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Product Name: 1-Fluoro-2,4-dinitrobenzene
Synonyms: Sanger’s reagent
CAS Number: 70-34-8
Molecular Formula: C6H3FN2O4
Molecular Weight: 186.10 g/mol
Recommended Use: Research chemical, protein sequencing
Supplier: Provided upon request at point of sale, often tracked or logged for audit
Emergency Phone: Check with regional poison control center or local health authority for chemical incident support
GHS Classification: Acute toxicity, Oral (Category 3); Skin corrosion/irritation (Category 2); Eye damage/irritation (Category 1); Specific target organ toxicity - single exposure (Category 3)
Signal Word: Danger
Hazard Statements: Toxic if swallowed; causes severe skin burns and eye damage; may cause respiratory irritation
Precautionary Statements: Avoid breathing dust or vapors; wash hands thoroughly after handling; use only outdoors or in a well-ventilated area; wear protective gloves, clothing, eye protection, face protection
Routes of Exposure: Inhalation, ingestion, skin, and eye contact; all present risk of acute toxicity
Chemical Name: 1-Fluoro-2,4-dinitrobenzene
CAS Number: 70-34-8
Concentration: 98-100%
Impurities: Product purity generally above laboratory reagent standards; trace contaminants rare but may influence handling in some settings
Formula: C6H3FN2O4
General Advice: Remove individual from exposure, seek fresh air, consult medical personnel immediately; document exposure for medical staff
Inhalation: Move person to fresh air; rest in semi-upright position; provide oxygen if breathing is difficult; call emergency services
Skin Contact: Remove any contaminated clothing right away; wash skin with soap and large volumes of water for at least 15 minutes; attention to rapid onset of irritation
Eye Contact: Rinse cautiously with water for several minutes; hold eyelid open, continue rinsing; seek urgent ophthalmologist exam
Ingestion: Rinse mouth, do not induce vomiting; never give fluids if unconscious; immediate medical attention critical. Onset of symptoms may be rapid
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam; water spray to cool surfaces only
Special Hazards: Releases toxic gases when burned, like nitrogen oxides and hydrogen fluoride
Protective Equipment: Self-contained breathing apparatus (SCBA); protective suit
Firefighting Precautions: Keep away from ignition sources; evacuate area; approach fire from upwind; contaminated runoff control important to reduce spread into environment
Personal Precautions: Wear full protective clothing including gloves, goggles, and face shield; control dust formation by dampening spills
Emergency Procedures: Evacuate unprotected personnel; ventilate contaminated area; inform trained response teams
Cleanup Methods: Use inert absorbent material, collect in sealed and labeled containers for hazardous disposal; avoid creating aerosols; wash contaminated surfaces thoroughly, ensure runoff containment
Safe Handling: Use chemical fume hood, avoid inhalation or skin contact; transfer only with properly grounded containers and proper tools; eating, drinking, or smoking not permitted in handling areas
Storage Conditions: Store locked and segregated in dry, well-ventilated areas; keep containers tightly closed; avoid humidity and temperatures outside 2–8°C
Storage Incompatibilities: Avoid storing near strong bases, reducing agents, combustible materials, or acids; vigilant labeling, separation, and inspection of stored inventory
Engineering Controls: Laboratory-grade ventilation, local exhaust recommended; emergency eye wash station and safety shower must be available
Eye/Face Protection: Tight-fitting chemical safety goggles, face shield
Skin Protection: Nitrile or neoprene gloves, long-sleeved lab coat, closed footwear
Respiratory Protection: Air-purifying respirators with appropriate filter for organic vapors if above permissible limits or during spill cleanup
Occupational Exposure Limits: No established OSHA/ACGIH values; minimize airborne concentrations
Hygiene Measures: No eating, drinking, or smoking during use; wash thoroughly after handling; keep contaminated work clothing away from living spaces
Appearance: Crystalline yellow solid
Odor: Sharp, pungent odor, similar to other nitrobenzene derivatives
Melting Point: 173-175°C
Boiling Point: Not readily available, decomposes before boiling
Solubility: Slightly soluble in water; more soluble in ethanol, acetone, and other organic solvents
pH: Not applicable
Vapor Pressure: Negligible at room temperature
Flash Point: Not determined, expected to be high due to low volatility and solid state
Density: 1.60 g/cm3 approximately
Partition coefficient: log Kow approximately 1.87
Autoignition Temperature: Data not available
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong bases, reducing agents, and compounds susceptible to nucleophilic aromatic substitution
Hazardous Reactions: Potential for violent reaction with alkali metals or alkoxides; avoid exposure to excessive heat or incompatible materials
Decomposition Products: Toxic fumes, including fluorinated and nitro compounds; nitrogen oxides, hydrogen fluoride release likely on thermal decomposition
Polymerization: No hazardous polymerization anticipated under normal conditions
Acute Toxicity: Oral LD50 in rats reported as about 200 mg/kg, reflecting significant toxicity
Skin Irritation: Causes redness, blistering, or severe irritation on contact
Eye Damage: Risk of severe burns, potential vision impairment
Inhalation: Respiratory tract irritation, headache, nausea, possible lung injury at high concentration
Chronic Effects: Not fully characterized, repeated exposure potentially damages internal organs based on nitroaromatic toxicity
Carcinogenicity: No conclusive evidence in humans; animal studies limited; not classified as known carcinogen by IARC or NTP
Sensitization: May cause skin sensitization reactions in susceptible individuals
Other Effects: May cause hemolytic anemia or methemoglobinemia if absorbed systemically; report any exposure events to occupational health authorities
Ecotoxicity: Toxic to aquatic organisms, risk of long-term adverse effects in aquatic environment
Persistence and Degradability: Resistant to rapid biodegradation due to nitro groups; may persist in sediment and soils for extended periods
Bioaccumulation: Moderate potential, log Kow below threshold for most high-risk compounds but persistent
Mobility in Soil: Limited mobility, binds to organic matter; risk dependent on site-specific conditions
Other Adverse Effects: Avoid release into surface or groundwater; careful management of wastewater required
Disposal Methods: Treat as hazardous waste; incineration in a licensed facility with flue gas scrubbers
Container Handling: Triple rinse containers and manage as hazardous; never reuse for any other purpose
Disposal Regulations: Always follow regional, national, and international disposal requirements; coordinate with local environmental authorities
Spill Disposal: Do not allow into sewers, surface water, or natural water sources; specialized environmental contractor best suited for cleanup and removal
UN Number: 2811
Proper Shipping Name: Toxic solids, organic, n.o.s. (1-Fluoro-2,4-dinitrobenzene)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Marine Pollutant: Not classified as marine pollutant under IMDG but releases must still be controlled
Transport Precautions: Secure containers against tipping, falling, or damage; preserve documentation for regulatory inspection during transit
US TSCA: Listed for lawful manufacturing and handling; not exempt from reporting
EU REACH: Compliant within permitted volumes for research and development; extra authorization required for bulk purchases
SARA Title III Sections 302/313: Not listed as an extremely hazardous substance, but near relatives of substance class are monitored
California Proposition 65: No explicit listing, but review stays prudent for evolving scientific findings
Other Regional Regulations: Manage as toxic industrial reagent; libraries and research operations need documented safety programs, frequent inspection, and up-to-date spill response preparedness
