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MSDS Commentary for γ-Aminobutyric Acid

Identification

Chemical Name: γ-Aminobutyric Acid
Synonyms: GABA
Chemical Formula: C4H9NO2
Common Form: Off-white powder or crystals
CAS Number: 56-12-2
Intended Use: Laboratory chemical, research applications, pharmaceutical intermediate

Hazard Identification

GHS Classification: Substance generally regarded as low-hazard under normal conditions
Signal Word: Not classified as hazardous by OSHA standards
Potential Hazards: May cause eye, skin, and respiratory discomfort if handled improperly
Symptoms of Overexposure: Mild irritation, possible headache or dizziness if dust is inhaled in large amounts
Label Elements: Not required for most consumer or industrial handling

Composition / Information on Ingredients

Main Ingredient: γ-Aminobutyric Acid (≥98%)
Impurities: Trace organic by-products, residual solvents possible depending on synthesis route

First Aid Measures

Eye Contact: Flush with clean water for several minutes; seek medical help if irritation sticks around
Skin Contact: Wash exposed area thoroughly with soap and water
Inhalation: Move to fresh air; deep breaths and quiet space usually solve mild breathing discomfort
Ingestion: Rinse mouth and drink water; if symptoms feel severe, medical attention makes sense
Most Notable Effects: Rarely more than local discomfort but always better to play it safe

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, or water spray
Hazards Combustion Products: Fires may create carbon oxides, nitrogen oxides
Protective Equipment: Firefighters should grab full protective gear, stay upwind, and avoid dust inhalation
Typical Fire Behavior: GABA doesn’t catch easily, but dust clouds in confined spaces can ignite under extreme heat

Accidental Release Measures

Personal Precautions: Avoid dust formation; work in ventilated area
Protective Equipment: Gloves, safety glasses, suitable dust mask if working with spills in bulk
Environmental Precautions: Keep from drains and surface water if handling large spills
Cleanup Method: Sweep up material, place in appropriate closed container for disposal, wash area to remove residues

Handling and Storage

Handling: Keep containers tightly closed to avoid spills; avoid creating and breathing dust
Storage Conditions: Store cool, dry, and away from strong acids or oxidizing agents; normal light and room temperature do the job
Incompatible Materials: Strong oxidizers, strong acids, avoid sources of static electricity

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation or work in fume hood if dust is getting airborne
Personal Protection: Gloves for bulk handling, safety goggles for any work that may send powder drifting
Respiratory Protection: Dust mask or respirator in poorly ventilated or high-dust settings
Workplace Practices: Wash hands after handling; don’t eat or drink near active materials
Exposure Limits: Not yet established by OSHA, NIOSH or ACGIH, reflect generally low toxicity profile in routine settings

Physical and Chemical Properties

Appearance: Nearly white crystal or powder
Odor: No significant odor
Melting Point: Usually melts above 200°C
Solubility: Soluble in water; very low solubility in most organic solvents
pH (1% solution): Mildly acidic to near-neutral
Boiling Point: Not typically observed before decomposition
Vapor Pressure: Not available; negligible at room temperature
Flash Point: Not considered flammable under most conditions

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and storage conditions
Reactivity: Not particularly reactive, but can break down in strong acid or base environments
Conditions to Avoid: Strong oxidizing conditions, heat above decomposition
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides can form at high heat

Toxicological Information

Acute Effects: Low oral toxicity; has little to no negative effect through typical skin exposure
Chronic Exposure: No solid evidence points to long-term risks in everyday lab use
Possible Routes: Inhalation, ingestion, skin and eye contact
Symptoms of Exposure: Irritation, possible mild drowsiness if ingested in large amounts
Carcinogenic Status: Not listed as carcinogenic by IARC, NTP, or OSHA

Ecological Information

Ecotoxicity: No major environmental impact expected based on available studies; not considered persistent
Mobility: Soluble in water; can move through soil and water systems if released
Bioaccumulation Potential: No significant bioaccumulation expected
Degradability: Readily broken down by soil and water microbes

Disposal Considerations

Waste Handling: Sweep up residuals and dispose according to government, regional, and local rules
Disposal Methods: Usually landfilled or incinerated with regular chemical waste, as appropriate for non-hazardous lab chemicals
Avoid: Do not flush to drains or natural water bodies, especially in commercial settings

Transport Information

Transport Status: Not classified as hazardous for transport by land, air, or sea
Proper Shipping Name: No special designation under typical chemical standards
Packing and Shipping: Use sturdy, labeled containers; secure loads to prevent spillage
UN Number: None assigned for GABA

Regulatory Information

International Guidelines: Not listed by key regulatory frameworks as controlled or hazardous
OSHA Status: Not classified as hazardous
REACH/TSCA: Registered or listed as a standard chemical substance
Labeling Requirements: Minimal beyond standard chemical labeling rules